FAT1 information

FAT1
Identifiers
Aliases	FAT1, CDHF7, CDHR8, FAT, ME5, hFat1, FAT atypical cadherin 1
External IDs	OMIM: 600976; MGI: 109168; HomoloGene: 66302; GeneCards: FAT1; OMA:FAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	186,726,722 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	45,505,294 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; tibia; ; metanephric glomerulus; ; periodontal fiber; ; ventricular zone; ; cartilage tissue; ; stromal cell of endometrium; ; jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon;
	Top expressed in
	hand; ; ciliary body; ; stroma of bone marrow; ; iris; ; molar; ; cumulus cell; ; medullary collecting duct; ; calvaria; ; renal corpuscle; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; cell-cell junction; focal adhesion; filopodium; plasma membrane; integral component of plasma membrane; cell junction; perinuclear region of cytoplasm; extracellular exosome; nucleus; lamellipodium; apical plasma membrane;
Biological process	actin filament organization; cell-cell signaling; anatomical structure morphogenesis; establishment or maintenance of cell polarity; cell adhesion; cell migration; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell adhesion; epithelial cell morphogenesis; establishment or maintenance of epithelial cell apical/basal polarity; camera-type eye morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2195
	14107
	ENSG00000083857
	ENSMUSG00000070047
	Q14517
	n/a
	NM_005245
	NM_001081286; NM_010179
	NP_005236
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin FAT1 is a protein that in humans is encoded by the FAT1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000083857 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070047 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, et al. (November 1995). "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule". Genomics. 30 (2): 207–23. doi:10.1006/geno.1995.9884. PMID 8586420.
^ "Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000083857 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070047 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586420-5] Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, et al. (November 1995). "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule". Genomics. 30 (2): 207–23. doi:10.1006/geno.1995.9884. PMID 8586420.

[entrez-6] "Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila)".

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