Glypican 4 information

GPC4
Identifiers
Aliases	GPC4, K-glypican, glypican 4, KPTS
External IDs	OMIM: 300168 MGI: 104902 HomoloGene: 55582 GeneCards: GPC4
Gene location (Human)
Chr.	X chromosome (human)
End	133,415,489 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	51,254,129 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; gastric mucosa; ; right lung; ; thoracic aorta; ; ascending aorta; ; popliteal artery; ; left coronary artery; ; biceps brachii; ; right coronary artery; ; tibia;
	Top expressed in
	cumulus cell; ; ascending aorta; ; kidney; ; calvaria; ; aortic valve; ; molar; ; ciliary body; ; pituitary gland; ; Paneth cell; ; adrenal medulla;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway;
Cellular component	membrane; plasma membrane; integral component of plasma membrane; extracellular region; lysosomal lumen; Golgi lumen; anchored component of membrane; extracellular exosome; external side of plasma membrane; nucleus; extracellular space; synapse; anchored component of plasma membrane; collagen-containing extracellular matrix; glutamatergic synapse; anchored component of presynaptic membrane; cell surface;
Biological process	glycosaminoglycan metabolic process; anatomical structure morphogenesis; retinoid metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan biosynthetic process; cell population proliferation; Wnt signaling pathway, planar cell polarity pathway; regulation of signal transduction; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; synaptic membrane adhesion; regulation of presynapse assembly; cell migration; regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	2239
	14735
	ENSG00000076716
	ENSMUSG00000031119
	O75487
	P51655
	NM_001448
	NM_008150
	NP_001439
	NP_032176
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican-4 is a protein that in humans is encoded by the GPC4 gene.^[5]^[6]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000076716 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (October 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.
^ ^a ^b "Entrez Gene: GPC4 glypican 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000076716 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031119 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9787072-5] Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (October 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.

[entrez-6] "Entrez Gene: GPC4 glypican 4".

Glypican 4 information

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