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The native form of this personal name is Mak Tak-wah. This article uses Western name order when mentioning individuals.
In this Chinese name, the family name is Mak.
Tak Wah Mak
Born
(1946-10-04) October 4, 1946 (age 77)[1][2]
China
Nationality
Canadian
Alma mater
Wah Yan College, Kowloon University of Wisconsin University of Alberta
Known for
Discovery of the T-cell receptor
Discovery of the function of CTLA-4
Founder of Agios Pharmaceuticals
Scientific career
Fields
Biochemistry Immunology Biology
Institutions
Princess Margaret Cancer Centre University Health Network University of Toronto
Academic advisors
Howard Martin Temin Ernest McCulloch James Till
Tak Wah Mak, OC OOnt FRS FRSC (simplified Chinese: 麦德华; traditional Chinese: 麥德華; pinyin: Mài Déhuá; born October 4, 1946, in China) is a Canadian medical researcher, geneticist, oncologist, and biochemist. He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology.[3] In 1995, Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment.[4] Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for acute myeloid leukemia in August 2017, becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment.[5] He has worked in a variety of areas including biochemistry, immunology, and cancer genetics.
^"Science.ca: Tak Wah Mak".
^"Tak Wah Mak | Living History". Archived from the original on 2016-03-04. Retrieved 2014-02-23.
^Viegas, J. (2011). "Profile of Tak Wah Mak". Proceedings of the National Academy of Sciences. 108 (48): 19124–6. Bibcode:2011PNAS..10819124V. doi:10.1073/pnas.1116912108. PMC 3228474. PMID 22080609.
^Waterhouse, Paul; Penninger, Josef M.; Timms, Emma; Wakeham, Andrew; Shahinian, Arda; Lee, Kelvin P.; Thompson, Craig B.; Griesser, Henrik; Mak, Tak W. (1995-11-10). "Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4". Science. 270 (5238): 985–988. Bibcode:1995Sci...270..985W. doi:10.1126/science.270.5238.985. ISSN 0036-8075. PMID 7481803. S2CID 45993765.
^"FDA Grants Approval of IDHIFA®, the First Oral Targeted Therapy for Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and an IDH2 Mutation | Agios Pharmaceuticals, Inc. – IR Site". Agios Pharmaceuticals, Inc. – IR Site. Retrieved 2017-08-04.
TakWahMak, OC OOnt FRS FRSC (simplified Chinese: 麦德华; traditional Chinese: 麥德華; pinyin: Mài Déhuá; born October 4, 1946, in China) is a Canadian medical...
member Ludwig von Bertalanffy, for his work systems theory, and alumnus TakWahMak, discoverer of the T-cell receptor. Eric Allan Kramer graduated from...
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Cochrane Phil Gold James C. Hogg Vera Peters Calvin Stiller Sylvia Fedoruk TakWahMak Ronald Melzack Charles Tator Mladen Vranic Elizabeth Bagshaw Felix d'Herelle...
botanist, cytologist, horticulturalist John Macoun (1831–1920) – botanist TakWahMak (born 1946) – immunologist who discovered the T-cell receptor Claude...
Toronto Department of Immunology in 1988. Her graduate supervisor was TakWahMak. In her undergraduate studies at York University, Ohashi did wet lab...
drug resistance in cancer; known for his discovery of P-glycoprotein TakWahMak, medical researcher, geneticist, oncologist, and biochemist; known for...
Centre for Applied Genomics (TCAG) at the Hospital for Sick Children. TakWahMak, professor of medical biophysics, 1975–: Discovered the T-cell receptor...
(1909–1972), Canadian-American co-discoverer that DNA is the genetic material TakWahMak (born 1946), Chinese-Canadian molecular biologist, co-discovered human...
executive officer of Affinium Pharmaceuticals, Ltd., which was founded by TakWahMak, Aled Edwards, Cheryl Arrowsmith and Jack Greenblatt and since acquired...
understanding of the mechanism of ion transport by SR calcium pumps TakWahMak (professor of medical biophysics, 1975–) – immunologist who discovered...
theoretical physicist (Istituto Massimo) TakWahMak - Canadian immunologist, molecular biologist, and academic (Wah Yan College, Kowloon, Hong Kong) Louis...
Rockville 2003 Richard A. Lerner, La Jolla Peter G. Schultz, La Jolla 2004 TakWahMak, University of Toronto Mark M. Davis, Stanford University 2005 Ian Wilmut...
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