SLIT1 information

SLIT1
Identifiers
Aliases	SLIT1, MEGF4, SLIL1, SLIT-1, SLIT3, slit guidance ligand 1
External IDs	OMIM: 603742; MGI: 1315203; HomoloGene: 2302; GeneCards: SLIT1; OMA:SLIT1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,185,959 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,732,104 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; Brodmann area 10; ; Brodmann area 23; ; Brodmann area 46; ; entorhinal cortex; ; superior frontal gyrus; ; pancreatic ductal cell; ; frontal pole;
	Top expressed in
	superior frontal gyrus; ; urethra; ; male urethra; ; hippocampus proper; ; stellate reticulum; ; enamel knot; ; sensory ganglion; ; medullary collecting duct; ; enteric nervous system; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; Roundabout binding; heparin binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration; cell differentiation; neuron projection morphogenesis; dorsal/ventral axon guidance; negative chemotaxis; axonogenesis; negative regulation of synapse assembly; nervous system development; telencephalon cell migration; multicellular organism development; forebrain morphogenesis; tangential migration from the subventricular zone to the olfactory bulb; olfactory bulb development; motor neuron axon guidance; axon extension involved in axon guidance; retinal ganglion cell axon guidance; axon guidance; nuclear migration;
	Sources:Amigo / QuickGO
Orthologs
	6585
	20562
	ENSG00000187122
	ENSMUSG00000025020
	O75093
	Q80TR4
	NM_003061
	NM_015748
	NP_003052
	NP_056563
	Wikidata
View/Edit Human	View/Edit Mouse

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187122 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025020 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
^ Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
^ "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187122 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693030-5] Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.

[pmid9813312-6] Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.

[entrez-7] "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)".

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