Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Gliotoxin is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines[1] produced by several species of fungi, especially those of marine origin. It is the most prominent member of the epipolythiopiperazines, a large class of natural products featuring a diketopiperazine with di- or polysulfide linkage. These highly bioactive compounds have been the subject of numerous studies aimed at new therapeutics.[2] Gliotoxin was originally isolated from Gliocladium fimbriatum, and was named accordingly. It is an epipolythiodioxopiperazine metabolite that is one of the most abundantly produced metabolites in human invasive Aspergillosis (IA).[3]
^Borthwick AD (2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". Chemical Reviews. 112 (7): 3641–3716. doi:10.1021/cr200398y. PMID 22575049.
^Jiang CS, Muller WE, Schroder HC, Guo YW (2012). "Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms". Chem. Rev. 112 (4): 2179–2207. doi:10.1021/cr200173z. PMID 22176580.
^Lewis RE, Wiederhold NP, Chi J, Han XY, Komanduri KV, Kontoyiannis DP, Prince RA (January 2005). "Detection of Gliotoxin in Experimental and Human Aspergillosis". Infection and Immunity. 73 (1): 635–637. doi:10.1128/IAI.73.1.635-637.2005. PMC 538950. PMID 15618207.
Gliotoxin is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by several species of fungi,...
Gliotoxin is a mycotoxin capable of altering host defenses through immunosuppression. Neutrophils are the principal targets of gliotoxin. Gliotoxin interrupts...
fingolimod precursor myriocin. Aspergillus synthesizes immunosuppressants gliotoxin and endocrocin. Subglutinols are immunosuppressants isolated from Fusarium...
cyclopiazonic acid, kojic acid, β-nitropropionic acid, aspertoxin, aflatrem, gliotoxin, and aspergillic acid. In humans, A. flavus aflatoxin production can lead...
Penicillin and cephalosporin are life-saving antibiotics, derived from fungi. Gliotoxin is a sulfur-containing mycotoxin produced by several species of fungi...
cytochalasin-like compounds, fiscalin-like compounds, pyripyropens, and gliotoxin. A. thermomutatus has been cultivated on both Czapek yeast extract agar...
agent in humans and animals. Gliotoxin is a metabolite of G. (now Trichoderma) deliquescens. The significance of gliotoxin has not yet been determined...
career Institutions Harvard University Rice University University of Tokyo Thesis The total synthesis of gliotoxin (1977) Doctoral advisor Yoshito Kishi...
Johnson, J. R.; Hasbrouck, R. B.; Dutcher, J. D. & Bruce, W. F. (1945). "Gliotoxin. V. The Structure of Certain Indole Derivatives Related to Gliotoxin1...
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