Cartoon representation of the diphtheria toxin protein
Identifiers
Organism
Corynebacterium diphtheriae
Symbol
tox
Entrez
2650491
RefSeq (Prot)
NP_938615
UniProt
P00587
Other data
EC number
2.4.2.36
Chromosome
genome: 0.19 - 0.19 Mb
Search for
Structures
Swiss-model
Domains
InterPro
Diphtheria toxin, C domain
Identifiers
Symbol
Diphtheria_C
Pfam
PF02763
Pfam clan
CL0084
InterPro
IPR022406
SCOP2
1ddt / SCOPe / SUPFAM
TCDB
1.C.7
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Diphtheria toxin, T domain
Identifiers
Symbol
Diphtheria_T
Pfam
PF02764
InterPro
IPR022405
SCOP2
1ddt / SCOPe / SUPFAM
TCDB
1.C.7
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Diphtheria toxin, R domain
Identifiers
Symbol
Diphtheria_R
Pfam
PF01324
InterPro
IPR022404
SCOP2
1ddt / SCOPe / SUPFAM
TCDB
1.C.7
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Diphtheria toxin is an exotoxin secreted mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, the pathogenic bacterium that causes diphtheria. The toxin gene is encoded by a prophage[annotation 1] called corynephage β.[1][2]
The toxin causes the disease in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis.[3]
Cite error: There are <ref group=annotation> tags on this page, but the references will not show without a {{reflist|group=annotation}} template (see the help page).
^TABLE 1. Bacterial virulence properties altered by bacteriophages from Wagner PL, Waldor MK (August 2002). "Bacteriophage control of bacterial virulence". Infection and Immunity. 70 (8): 3985–93. doi:10.1128/IAI.70.8.3985-3993.2002. PMC 128183. PMID 12117903.
^Johnson LP, Tomai MA, Schlievert PM (May 1986). "Bacteriophage Involvement in Group A Streptococcal Pyrogenic Exotoxin A Production". Journal of Bacteriology. 166 (2): 623–7. doi:10.1128/jb.166.2.623-627.1986. PMC 214650. PMID 3009415.
^Bell CE, Eisenberg D (January 1996). "Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide". Biochemistry. 35 (4): 1137–49. doi:10.1021/bi9520848. PMID 8573568.
Diphtheriatoxin is an exotoxin secreted mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis...
been found in some animals, which would suggest zoonotic potential. Diphtheriatoxin (DT) is produced only by C. diphtheriae infected with a certain type...
bacteriophage that carries a gene that gives rise to a toxin. This toxin causes the disease. Diphtheria is caused by the adhesion and infiltration of the bacteria...
Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheriatoxin. It works by neutralizing the toxins produced...
example, diphtheriatoxin is only produced by Corynebacterium diphtheriae bacteria and is required for the diphtheria disease. Some bacterial toxins can be...
botulinum toxin produced by Clostridium botulinum; Corynebacterium diphtheriae toxin, produced during life-threatening symptoms of diphtheria; tetanospasmin...
; Strom, T. B. (1987). "Genetic assembly and selective toxicity of diphtheria-toxin-related polypeptide hormone fusion proteins". Biochemical Society Symposium...
CRM197 is a non-toxic mutant of diphtheriatoxin, currently used as a carrier protein for polysaccharides and haptens to make them immunogenic. There is...
ml) of diluted (1/50 MLD) diphtheriatoxin is injected intradermally into one arm of the person and a heat inactivated toxin on the other as a control...
pit formation in Hep2 cells blocks the cytotoxicity of diphtheriatoxin but not that of ricin toxin". J. Cell Biol. 101 (2): 548–559. doi:10.1083/jcb.101...
anthrax toxin, and translocates the A moiety into host cells after assembling as a heptamer in the membrane. The Diphtheriatoxin also is an AB toxin. It...
without resulting in toxin-induced illness. Such a preparation is also known as an anatoxin. There are toxoids for prevention of diphtheria, tetanus and botulism...
Tetanus toxin (TeNT) is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani in anaerobic conditions, causing tetanus...
antitoxin. Botulinum toxins are AB toxins and closely related to Anthrax toxin, Diphtheriatoxin, and in particular tetanus toxin. The two are collectively...
surface of muscle cells and cause depolarisation → the toxin prevents muscle contraction. These toxins may cause the heart to beat irregularly or stop beating...
Neurotoxins are toxins that are destructive to nerve tissue (causing neurotoxicity). Neurotoxins are an extensive class of exogenous chemical neurological...
spore-forming, motile bacterium with the ability to produce botulinum toxin, which is a neurotoxin. C. botulinum is a diverse group of pathogenic bacteria...
potent known exotoxins are the tetanus toxin (tetanospasmin) secreted by Clostridium tetani and the botulinum toxin secreted by Clostridium botulinum. Exotoxins...
infectious diseases in humans: diphtheria, pertussis (whooping cough), and tetanus (lockjaw). The vaccine components include diphtheria and tetanus toxoids, and...
vaccines for both diphtheria and tetanus. In particular, he developed a method for inactivating the diphtheriatoxin and the tetanus toxin using formaldehyde...
causative agent of classical diphtheria, and C. ulcerans has been found to carry the same gene that codes for the diphtheriatoxin. After swabbing lesions...
Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages...
containing diphtheria antitoxin (antibodies against diphtheriatoxin). Jim produced over 30 US quarts (7.5 US gallons; 28.5 litres) of diphtheria antitoxin...
elongation of polypeptides to cease. This mechanism is similar to that of diphtheriatoxin. It has been investigated as a treatment for hepatitis B and cancer...
awarded. By 1913, Behring had created Antitoxin-Toxin (antibody-antigen) complexes to produce the diphtheria AT vaccine. In the 1920s, Gaston Ramon developed...
improve the environment for further fungal proliferation. The production of toxins depends on the surrounding intrinsic and extrinsic environments and these...
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