negative regulation of transcription, DNA-templated
regulation of DNA replication
positive regulation of chromatin binding
DNA replication preinitiation complex assembly
negative regulation of DNA-dependent DNA replication
protein-containing complex assembly
G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51053
57441
Ensembl
ENSG00000112312
ENSMUSG00000006715
UniProt
O75496
O88513
RefSeq (mRNA)
NM_001251989 NM_001251990 NM_001251991 NM_015895
NM_020567
RefSeq (protein)
NP_001238918 NP_001238919 NP_001238920 NP_056979
NP_065592
Location (UCSC)
Chr 6: 24.77 – 24.79 Mb
Chr 13: 24.94 – 24.95 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene.[5] A nuclear protein present in most eukaryotes and highly conserved across species, numerous functions have been elucidated for geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation.[6] One example of its function is the inhibition of Cdt1.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000112312 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000006715 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: GMNN geminin, DNA replication inhibitor".
^Kroll KL (2007). "Geminin in embryonic development: coordinating transcription and the cell cycle during differentiation". Frontiers in Bioscience. 12 (4): 1395–1409. doi:10.2741/2156. PMID 17127390.
^Alberts, Bruce (18 November 2014). Molecular biology of the cell (Sixth ed.). New York, NY. p. 975. ISBN 978-0-8153-4432-2. OCLC 887605755.{{cite book}}: CS1 maint: location missing publisher (link)
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. A nuclear protein present in most eukaryotes...
the cell cycle is tightly regulated during the S phase by the protein geminin, which inhibits it, and by SCFSKP2, which ubiquinates the protein to tag...
complex. In G1, levels of geminin are kept low by the APC, which ubiquitinates geminin to target it for degradation. When geminin is destroyed, Cdt1 is released...
of a protein known as geminin. Geminin binds tightly to Cdt1 and is thought to be the major inhibitor of re-replication. Geminin first appears in S-phase...
define novel regulators of early embryonic development. These included Geminin (Gmnn), a novel nuclear protein that she identified based on its ability...
subunit six) and its role in viral DNA replication. He also identified geminin, a replication inhibitor, as a blocking factor of viral DNA replication...
October 2007. Retrieved 4 May 2024. "Aihe: Star Cruises myy SuperStar Geminin". Maritimforum (in Finnish). Finland. Archived from the original on 9 August...
acetylase activity is essential for DNA replication licensing and inhibited by Geminin". Molecular Cell. 37 (1): 57–66. doi:10.1016/j.molcel.2009.12.012. PMC 2818871...
even if one of the components fails. Geminin is an important inhibitor of pre-Rc assembly is metazoan cells. Geminin was identified in a screen for APC/C...
downregulation of APC-Cdh1-mediated proteolysis and accumulation of the protein Geminin, which is responsible for sequestration of the pre-RC component Cdt1. Oscillations...
D, Kyrousi C, Lygerou Z, Taraviras S (February 2017). "Concise Review: Geminin-A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation...
regulators (Orc3, Orc4, Orc5, Orc6, Cdc6, Cdt1, Cdc45, Mcm10, geminin) and identified how the geminin-Cdt1 balance is important for the prevention of over-replication...
initiation of eukaryotic DNA replication at the origin, Cdt1 is inactivated by Geminin and targeted for degradation by the SCFSkp2 and CRL4Cdt2 complexes. Cdt1...
PMID 11788828. S2CID 21430931. Yanagi K, Mizuno T, You Z, Hanaoka F (2002). "Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1...
of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin Translation of cyclin mRNA is necessary for extracts of activated Xenopus...
by the ubiquitin-proteasome pathway. Two fluorescent probes - Cdt1 and Geminin conjugated to fluorescent proteins - allow for real-time visualization...
Akbay'ın ailesi yeni öğrendi! Aysun, Somali'de kaçırılan "Horizon-1" adlı geminin 4. kaptanı!" (in Turkish). Hurriyetport. Archived from the original on...
from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin". Cell. 106 (3): 287–296. doi:10.1016/S0092-8674(01)00458-5. PMID 11509178...
Takihara Y, Knoetgen H, Kessel M (February 2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions"...
et al. (August 2006). "A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells"...
Takihara Y, Knoetgen H, Kessel M (Feb 2004). "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions"...
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