Endoreduplication (also referred to as endoreplication or endocycling) is replication of the nuclear genome in the absence of mitosis, which leads to elevated nuclear gene content and polyploidy. Endoreduplication can be understood simply as a variant form of the mitotic cell cycle (G1-S-G2-M) in which mitosis is circumvented entirely, due to modulation of cyclin-dependent kinase (CDK) activity.[1][2][3][4] Examples of endoreduplication characterised in arthropod, mammalian, and plant species suggest that it is a universal developmental mechanism responsible for the differentiation and morphogenesis of cell types that fulfill an array of biological functions.[1][2] While endoreduplication is often limited to specific cell types in animals, it is considerably more widespread in plants, such that polyploidy can be detected in the majority of plant tissues.[5] Polyploidy and aneuploidy are common phenomena in cancer cells.[6] Given that oncogenesis and endoreduplication likely involve subversion of common cell cycle regulatory mechanisms, a thorough understanding of endoreduplication may provide important insights for cancer biology.
^ abEdgar BA, Orr-Weaver TL (2001). "Endoreplication cell cycles: more for less". Cell. 105 (3): 297–306. doi:10.1016/S0092-8674(01)00334-8. PMID 11348589.
^Edgar BA, Zielke N, Gutierrez C (2014-02-21). "Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth". Nature Reviews Molecular Cell Biology. 15 (3): 197–210. doi:10.1038/nrm3756. ISSN 1471-0080. PMID 24556841. S2CID 641731.
^Orr-Weaver TL (2015). "When bigger is better: the role of polyploidy in organogenesis". Trends in Genetics. 31 (6): 307–315. doi:10.1016/j.tig.2015.03.011. PMC 4537166. PMID 25921783.
Endoreduplication (also referred to as endoreplication or endocycling) is replication of the nuclear genome in the absence of mitosis, which leads to...
organisms, many somatic cells are polyploid due to a process called endoreduplication, where duplication of the genome occurs without mitosis (cell division)...
chromosomes. Endoreduplication is found in many species and appears to be a normal part of development. Endomitosis is a variant of endoreduplication in which...
chromosomes of the larval salivary glands undergo many rounds of endoreduplication to produce large quantities of adhesive mucoprotein ("glue") before...
female's germ cells undergo a process of premeiotic genome doubling, or endoreduplication, so that two consecutive division cycles in the process of meiosis...
original somatic number of chromosomes. In the endocycle (endomitosis or endoreduplication) chromosomes in a 'resting' nucleus undergo reduplication, the daughter...
followed by a duplication of all chromosomes/genes (a process called endoreduplication). In approximately 20% of complete moles, the most probable mechanism...
the megakaryoblast matures into the promegakaryocyte, it undergoes endoreduplication and forms a promegakaryocyte which has multiple nuclei, azurophilic...
one copy and leave two copies of second genome, they don't perform endoreduplication. Moreover, this not eliminated genome is transmitted to haploid gametes...
process chromosome segregation cell division negative regulation of DNA endoreduplication meiosis cell cycle sister chromatid cohesion regulation of mitotic...
(2012). "A multivariate analysis of variation in genome size and endoreduplication in angiosperms reveals strong phylogenetic signal and association...
kinds of genetic phenomena, including nondisjunction of chromosomes, endoreduplication, or mutations in individual stem cell lineages during the early development...
regulation of autophagy of mitochondrion negative regulation of DNA endoreduplication positive regulation of ubiquitin-protein transferase activity positive...
desumoylation negative regulation of protein binding regulation of DNA endoreduplication negative regulation of chromatin binding negative regulation of DNA...
G2/M transition of mitotic cell cycle negative regulation of DNA endoreduplication positive regulation of osteoblast differentiation negative regulation...
heterozygous individuals. The other is self-diploidization by haploid endoreduplication under the acetic acid stress, and turning out the homozygous individuals...
cell population maintenance cell division negative regulation of DNA endoreduplication cell cycle DNA repair sister chromatid cohesion mitotic cell cycle...
cycle negative regulation of cytokinesis positive regulation of DNA endoreduplication positive regulation of transcription by RNA polymerase II sprouting...
of protein import into nucleus cell population proliferation DNA endoreduplication microtubule cytoskeleton organization trophectodermal cell proliferation...
Global Information