SIX3 information

SIX3
Identifiers
Aliases	SIX3, HPE2, SIX homeobox 3
External IDs	OMIM: 603714 MGI: 102764 HomoloGene: 3947 GeneCards: SIX3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	44,946,071 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	85,936,730 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; nucleus accumbens; ; optic nerve; ; caudate nucleus; ; putamen; ; anterior pituitary; ; external globus pallidus; ; hypothalamus; ; islet of Langerhans; ; sperm;
	Top expressed in
	optic vesicle; ; pretectal area; ; subthalamus; ; zona incerta; ; suprachiasmatic nucleus; ; optic recess; ; thalamic reticular nucleus; ; nucleus accumbens; ; medial habenular nucleus; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; histone deacetylase binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription corepressor binding; signaling receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding;
Cellular component	nucleus; transcription regulator complex;
Biological process	eye development; forebrain anterior/posterior pattern specification; pituitary gland development; regulation of transcription, DNA-templated; negative regulation of neuron differentiation; proximal/distal axis specification; lens fiber cell apoptotic process; protein import into nucleus; neuroblast differentiation; forebrain dorsal/ventral pattern formation; optic vesicle morphogenesis; negative regulation of Wnt signaling pathway; apoptotic process involved in development; transcription by RNA polymerase II; regulation of neural precursor cell proliferation; transcription, DNA-templated; regulation of neural retina development; multicellular organism development; telencephalon regionalization; diencephalon development; telencephalon development; brain development; lens development in camera-type eye; lens fiber cell differentiation; regulation of cell population proliferation; regulation of neuroblast proliferation; lens induction in camera-type eye; epithelial cell maturation; neuroblast migration; circadian behavior; camera-type eye development; negative regulation of transcription, DNA-templated; cell proliferation in forebrain; positive regulation of transcription by RNA polymerase II; visual perception; regulation of cell cycle phase transition; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	6496
	20473
	ENSG00000138083
	ENSMUSG00000038805
	O95343
	Q62233
	NM_005413
	NM_011381
	NP_005404
	NP_035511
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138083 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038805 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Granadino B, Gallardo ME, López-Ríos J, Sanz R, Ramos C, Ayuso C, Bovolenta P, Rodríguez de Córdoba S (Jan 1999). "Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene". Genomics. 55 (1): 100–5. doi:10.1006/geno.1998.5611. PMID 9889003.
^ Wallis DE, Roessler E, Hehr U, Nanni L, Wiltshire T, Richieri-Costa A, Gillessen-Kaesbach G, Zackai EH, Rommens J, Muenke M (Jun 1999). "Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly". Nature Genetics. 22 (2): 196–8. doi:10.1038/9718. PMID 10369266. S2CID 8319986.
^ "Entrez Gene: SIX3 sine oculis homeobox homolog 3 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138083 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038805 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9889003-5] Granadino B, Gallardo ME, López-Ríos J, Sanz R, Ramos C, Ayuso C, Bovolenta P, Rodríguez de Córdoba S (Jan 1999). "Genomic cloning, structure, expression pattern, and chromosomal location of the human SIX3 gene". Genomics. 55 (1): 100–5. doi:10.1006/geno.1998.5611. PMID 9889003.

[pmid10369266-6] Wallis DE, Roessler E, Hehr U, Nanni L, Wiltshire T, Richieri-Costa A, Gillessen-Kaesbach G, Zackai EH, Rommens J, Muenke M (Jun 1999). "Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly". Nature Genetics. 22 (2): 196–8. doi:10.1038/9718. PMID 10369266. S2CID 8319986.

[entrez-7] "Entrez Gene: SIX3 sine oculis homeobox homolog 3 (Drosophila)".

SIX3 information

and 28 Related for: SIX3 information

SIX3

Schizencephaly

CACI

Guillermo Oliver

Composition of the protocerebrum

Marine life

Asian Doll

Holoprosencephaly

Nuclear receptor 4A3

Six3OS1

Microphthalmia

Geminin

Homeobox

List of human transcription factors

List of distinct cell types in the adult human body

Retina

Marine invertebrates

XK aprosencephaly

Starlet sea anemone

Ganglionic eminence

Fungal effectors

Syndromic microphthalmia

Cerebral organoid

Arthropod head problem

PRDM12

Zona limitans intrathalamica

SIX4

TLE1