negative regulation of transcription by RNA polymerase II
DNA replication initiation
G1/S transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4999
18393
Ensembl
ENSG00000115942
ENSMUSG00000026037
UniProt
Q13416
Q60862
RefSeq (mRNA)
NM_006190
NM_001025378 NM_001271526 NM_008765
RefSeq (protein)
NP_006181
NP_001020549 NP_001258455 NP_032791
Location (UCSC)
Chr 2: 200.91 – 200.96 Mb
Chr 1: 58.5 – 58.54 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Origin recognition complex subunit 2
Identifiers
Symbol
ORC2
Pfam
PF04084
InterPro
IPR007220
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000115942 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026037 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Takahara K, Bong M, Brevard R, Eddy RL, Haley LL, Sait SJ, Shows TB, Hoffman GG, Greenspan DS (October 1996). "Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L". Genomics. 31 (1): 119–122. doi:10.1006/geno.1996.0018. PMID 8808289.
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. The origin recognition complex (ORC) is a highly...
origins of replication. The subunits of this complex are encoded by the ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes. ORC is a central component for eukaryotic...
structure of the S. cerevisiae ORC bound to ARS DNA has been determined. Orc1, Orc2, Orc3, Orc4, and Orc5 encircle the A element by means of two types of interactions...
levels of Ran-GTP inhibit kinetochore release of Bub1, Bub3, Mad2 and CENP-E. Orc2 (a protein that belongs to the origin recognition complex -ORC- implicated...
methyl CpG binding protein MeCP2, and the origin recognition complex protein ORC2. HP1 has a versatile structure with three main components; a chromodomain...
association in a contiguous region, spanning 20-50kb. In this direction, Orc2 (one protein included in the origin recognition complex, ORC, implicated...
protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated...
interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent...
reported for this gene. ORC3 has been shown to interact with: MCM4, MCM7, ORC2, ORC4, ORC5, and ORC6. GRCh38: Ensembl release 89: ENSG00000135336 – Ensembl...