PHC1 information

PHC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L8E
Identifiers
Aliases	PHC1, EDR1, HPH1, MCPH11, RAE28, polyhomeotic homolog 1
External IDs	OMIM: 602978; MGI: 103248; HomoloGene: 107079; GeneCards: PHC1; OMA:PHC1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,941,467 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,317,520 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; ganglionic eminence; ; canal of the cervix; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right coronary artery; ; tibial nerve; ; ascending aorta; ; popliteal artery;
	Top expressed in
	seminiferous tubule; ; primitive streak; ; maxillary prominence; ; internal carotid artery; ; somite; ; ganglionic eminence; ; external carotid artery; ; secondary oocyte; ; ureter; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; protein binding;
Cellular component	PcG protein complex; PRC1 complex; nucleus; nucleoplasm;
Biological process	multicellular organism development; histone ubiquitination; negative regulation of G0 to G1 transition;
	Sources:Amigo / QuickGO
Orthologs
	1911
	13619
	ENSG00000111752
	ENSMUSG00000040669
	P78364
	Q64028
	NM_004426
	NM_001042623; NM_001271579; NM_007905; NM_001355215
	NP_004417
NP_001036088; NP_001258508; NP_031931; NP_001342144; NP_001395176;
	NP_001395177; NP_001395178; NP_001395179
	Wikidata
View/Edit Human	View/Edit Mouse

Polyhomeotic-like protein 1 is a protein that in humans is encoded by the PHC1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111752 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040669 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP (Apr 1997). "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic". Molecular and Cellular Biology. 17 (4): 2326–35. doi:10.1128/mcb.17.4.2326. PMC 232081. PMID 9121482.
^ "Entrez Gene: PHC1 polyhomeotic homolog 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111752 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040669 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9121482-5] Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP (Apr 1997). "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic". Molecular and Cellular Biology. 17 (4): 2326–35. doi:10.1128/mcb.17.4.2326. PMC 232081. PMID 9121482.

[entrez-6] "Entrez Gene: PHC1 polyhomeotic homolog 1 (Drosophila)".

PHC1 information

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