Replication initiator 1 is a protein that in humans is encoded by the REPIN1 gene.[5][6] The protein helps enable RNA binding activity as a replication initiation-region protein. The make up of REPIN 1 include three zinc finger hand clusters that organize polydactyl zinc finger proteins containing 15 zinc finger DNA- binding motifs.[7] It has also been predicted to help in regulation of transcription via RNA polymerase II with it being located in the nucleoplasm. Expression of this protein has been seen in the colon, spleen, kidney, and 23 other tissues within the human body throughout.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000214022 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000052751 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Houchens CR, Montigny W, Zeltser L, Dailey L, Gilbert JM, Heintz NH (January 2000). "The dhfr oribeta-binding protein RIP60 contains 15 zinc fingers: DNA binding and looping by the central three fingers and an associated proline-rich region". Nucleic Acids Research. 28 (2): 570–581. doi:10.1093/nar/28.2.570. PMC 102514. PMID 10606657.
^"Entrez Gene: REPIN1 replication initiator 1".
^Heiker JT, Klöting N (2013-01-01). Litwack G (ed.). "Replication initiator 1 in adipose tissue function and human obesity". Vitamins and Hormones. 91. Academic Press: 97–105. doi:10.1016/B978-0-12-407766-9.00005-5. ISBN 9780124077669. PMID 23374714.
Replication initiator 1 is a protein that in humans is encoded by the REPIN1 gene. The protein helps enable RNA binding activity as a replication initiation-region...
ENSG00000104856 Rel Known motif – In vivo/Misc source [767] DKSAAAKYCCCB REPIN1 ENSG00000214022 C2H2 ZF Likely sequence specific TF according to literature...
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