positive regulation of cytosolic calcium ion concentration
response to glucose
generation of precursor metabolites and energy
activation of adenylate cyclase activity
response to calcium ion
cell surface receptor signaling pathway
gastric inhibitory peptide signaling pathway
response to axon injury
desensitization of G protein-coupled receptor signaling pathway
endocrine pancreas development
signal transduction
positive regulation of insulin secretion
G protein-coupled receptor signaling pathway
positive regulation of cAMP-mediated signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2696
381853
Ensembl
ENSG00000010310
ENSMUSG00000030406
UniProt
P48546
Q0P543
RefSeq (mRNA)
NM_000164 NM_001308418
NM_001080815
RefSeq (protein)
NP_000155 NP_001295347
NP_001074284
Location (UCSC)
Chr 19: 45.67 – 45.68 Mb
Chr 7: 18.89 – 18.9 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.[5][6]
GIP-R is a member of the class B family of G protein coupled receptors.[7] GIP-R is found on beta-cells in the pancreas[8][9] where it serves as the receptor for the hormone Gastric inhibitory polypeptide (GIP).
^ abcGRCh38: Ensembl release 89: ENSG00000010310 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030406 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stoffel M, Fernald AA, Le Beau MM, Bell GI (August 1995). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization". Genomics. 28 (3): 607–609. doi:10.1006/geno.1995.1203. PMID 7490109.
^"Gastrointestinal Hormones and Peptides". Archived from the original on 2007-12-06. Retrieved 2007-08-24.
^Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors". Recept. Channels. 8 (3–4): 179–188. doi:10.1080/10606820213687. PMID 12529935.
and 29 Related for: Gastric inhibitory polypeptide receptor information
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Gastricinhibitorypolypeptide (GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone of the secretin family of hormones...
peptide 1 receptor Glucagon-like peptide 2 receptorGastricinhibitorypolypeptidereceptor The first three receptors bind closely related peptide hormones...
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beta-cell research is very active yet many mysteries remain. Gastricinhibitorypolypeptidereceptor List of terms associated with diabetes Guangxitoxin Alpha...
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gastricinhibitorypolypeptide (GIP), a human hormone that stimulates the release of insulin from the pancreas. Tirzepatide is a linear polypeptide of...
neutralize the acidity of the gastric chyme. Gastricinhibitory peptide (GIP): This peptide decreases gastric motility and is produced by duodenal mucosal...
arcuate nucleus that secrete dopamine (a.k.a. Prolactin Inhibitory Hormone) to act on the D2 receptors of lactotrophs, causing inhibition of prolactin secretion...
glucagon-like peptide-1 (GLP-1) and gastricinhibitory peptide (GIP, also known as: glucose-dependent insulinotropic polypeptide). GIP is produced and secreted...
(GRP) and gastricinhibitorypolypeptide (GIP), which regulate gastrin production. Releasing hormones increase (or, in case of inhibitory factors, decrease)...
OCLC 1243000176. The binding of somatostatin to its receptor in the pancreas leads to activation of an inhibitory G protein, or Gi, structurally homologous to...
innate immune response to the commensal microbiota. K cells secrete gastricinhibitory peptide, an incretin, which also promotes triglyceride storage. K...
1016/S0014-4827(02)00094-0. PMID 12648473. Carpenter G (1987). "Receptors for epidermal growth factor and other polypeptide mitogens". Annual Review of Biochemistry. 56...
Glucagon/gastricinhibitorypolypeptide/secretin/vasoactive intestinal peptide hormones are a family of evolutionarily related peptide hormones that regulate...
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testosterone.[citation needed] Polypeptide growth factors include: EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface...
inhibitory hormone. They isolated a polypeptide as a by-product from purification of secretin on carboxymethyl cellulose. They named this polypeptide...
(2016). "Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are InhibitoryReceptors Affected?". Frontiers in Cellular Neuroscience...
type I receptors. There is also substantial evidence that TGF-β-dependent signaling via the SMAD-3 pathway is responsible for many of the inhibitory functions...
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