Structure of motilin in isotropic phospholipid bicellar solution.[1]
Identifiers
Symbol
Motilin_ghrelin
Pfam
PF04644
InterPro
IPR006738
SCOP2
1lbj / SCOPe / SUPFAM
OPM superfamily
145
OPM protein
1lbj
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Motilin
NMR solution structure of motilin in phospholipid bicellar solution.[1]
Identifiers
Symbol
MLN
NCBI gene
4295
HGNC
7141
OMIM
158270
PDB
1lbj
RefSeq
NM_001040109
UniProt
P12872
Other data
Locus
Chr. 6 p21.3-p21.2
Search for
Structures
Swiss-model
Domains
InterPro
Motilin is a 22-amino acid polypeptide hormone in the motilin family that, in humans, is encoded by the MLN gene.[2]
Motilin is secreted by endocrine Mo cells[3][4] (also referred to as M cells, which are not the same as the M cells, or microfold cells, found in Peyer's patches) that are numerous in crypts of the small intestine, especially in the duodenum and jejunum.[5] It is released into the general circulation in humans at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions; and it also stimulates endogenous release of the endocrine pancreas.[6] Based on amino acid sequence, motilin is unrelated to other hormones. Because of its ability to stimulate gastric activity, it was named "motilin." Apart from in humans, the motilin receptor has been identified in the gastrointestinal tracts of pigs, rats, cows, and cats, and in the central nervous system of rabbits.
^ abPDB: 1lbj; Andersson A, Mäler L (October 2002). "NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution". Journal of Biomolecular NMR. 24 (2): 103–12. doi:10.1023/A:1020902915969. PMID 12495026. S2CID 34766985.
^Daikh DI, Douglass JO, Adelman JP (October 1989). "Structure and expression of the human motilin gene". DNA. 8 (8): 615–21. doi:10.1089/dna.1989.8.615. PMID 2574660.
^Daniel EE (1990-12-11). Neuropeptide Function in the Gastrointestinal Tract. CRC Press. ISBN 9780849361586.
^Goswami C, Shimada Y, Yoshimura M, Mondal A, Oda S, Tanaka T, Sakai T, Sakata I (2015-06-26). "Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus". PLOS ONE. 10 (6): e0131554. Bibcode:2015PLoSO..1031554G. doi:10.1371/journal.pone.0131554. PMC 4482737. PMID 26115342.
^Poitras P, Peeters TL (February 2008). "Motilin". Current Opinion in Endocrinology, Diabetes and Obesity. 15 (1): 54–7. doi:10.1097/MED.0b013e3282f370af. PMID 18185063. S2CID 220582156.
^Itoh Z (1997). "Motilin and clinical application". Peptides. 18 (4): 593–608. doi:10.1016/S0196-9781(96)00333-6. PMID 9210180. S2CID 38242445.
Motilin is a 22-amino acid polypeptide hormone in the motilin family that, in humans, is encoded by the MLN gene. Motilin is secreted by endocrine Mo...
Motilin receptor is a G protein-coupled receptor (previously GPCR38) that binds motilin. It was first cloned in 1999 by Merck Laboratories. and scientists...
preproghrelin. It is homologous to promotilin; both are members of the motilin family. It is cleaved to produce proghrelin which is cleaved to produce...
abdominal pain, and vomiting, are very common because erythromycin is a motilin agonist. More serious side effects include arrhythmia with prolonged QT...
are commonly administered as prokinetics. Motilin administration causes phase III contractions, and so motilin agonists are another common prokinetic. Eradication...
throughout the intestinal tract. Hormones secreted include somatostatin, motilin, cholecystokinin, neurotensin, vasoactive intestinal peptide, and enteroglucagon...
polypeptide. Enterochromaffin cells of the pancreas secrete the hormones motilin, serotonin, and substance P. Inflammation of the pancreas is known as pancreatitis...
Itopride given as a single dose study found that it also raises levels of motilin, somatostatin and lowers levels of cholecystokinin, as well as adrenocorticotropic...
100 g ingested is excreted via urine. Xylitol ingestion also increases motilin secretion, which may be related to xylitol's ability to cause diarrhea...
intestinal peptide and gastric inhibitory peptide Somatostatin family Motilin family Substance P. Ghrelin is a peptide hormone released from the stomach...
Camicinal is a motilin agonist for the treatment of gastroparesis. Barshop K, Kuo B (January 2015). "The investigational drug camicinal for the treatment...
cholecystokinin. It may stimulate the migrating motor complex, synergistic with motilin. On fasting, pancreatic polypeptide concentration is 80 pg/ml; after the...
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