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Digestive enzyme information


Diagram of the digestive enzymes in the small intestine and pancreas

Digestive enzymes take part in the chemical process of digestion, which follows the mechanical process of digestion. Food consists of macromolecules of proteins, carbohydrates, and fats that need to be broken down chemically by digestive enzymes in the mouth, stomach, pancreas, and duodenum, before being able to be absorbed into the bloodstream.[1] Initial breakdown is achieved by chewing (mastication) and the use of digestive enzymes of saliva. Once in the stomach further mechanical churning takes place mixing the food with secreted gastric acid. Digestive gastric enzymes take part in some of the chemical process needed for absorption. Most of the enzymatic activity, and hence absorption takes place in the duodenum.[2][3]

Digestive enzymes are found in the digestive tracts of animals (including humans) and in the tracts of carnivorous plants, where they aid in the digestion of food, as well as inside cells, especially in their lysosomes, where they function to maintain cellular survival.[4][5]

Digestive enzymes are classified based on their target substrates: lipases split fatty acids into fats and oils;[6] proteases and peptidases split proteins into small peptides and amino acids;[7] amylases split carbohydrates such as starch and sugars into simple sugars such as glucose,[8] and nucleases split nucleic acids into nucleotides.[9]

  1. ^ Patricia, Justin J.; Dhamoon, Amit S. (2024). "Physiology, Digestion". StatPearls. StatPearls Publishing.
  2. ^ "22.10C: Digestive Processes of the Small Intestine". Medicine LibreTexts. 2018-07-22. Retrieved 2023-08-14.
  3. ^ Heda, Rajiv; Toro, Fadi; Tombazzi, Claudio R. (2024). "Physiology, Pepsin". StatPearls. StatPearls Publishing.
  4. ^ Freund, Matthias; Graus, Dorothea; Fleischmann, Andreas; Gilbert, Kadeem J; Lin, Qianshi; Renner, Tanya; Stigloher, Christian; Albert, Victor A; Hedrich, Rainer; Fukushima, Kenji (2022-05-23). "The digestive systems of carnivorous plants". Plant Physiology. 190 (1): 44–59. doi:10.1093/plphys/kiac232. ISSN 0032-0889. PMC 9434158. PMID 35604105.
  5. ^ "Enzymes: What Are Enzymes, Pancreas, Digestion & Liver Function". Cleveland Clinic. Retrieved 2023-08-14.
  6. ^ "Lipase | Fat-digesting, Pancreatic, Lipolytic | Britannica". www.britannica.com. Retrieved 2023-08-14.
  7. ^ "Proteolytic enzyme | Description, Types, & Functions | Britannica". www.britannica.com. Retrieved 2023-08-14.
  8. ^ "3.3: Digestion and Absorption of Carbohydrates". Medicine LibreTexts. 2017-06-14. Retrieved 2023-08-14.
  9. ^ "Pancreatic nucleases - Big Chemical Encyclopedia". chempedia.info. Retrieved 2023-08-14.

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Digestive enzyme

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Digestive enzymes take part in the chemical process of digestion, which follows the mechanical process of digestion. Food consists of macromolecules of...

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Human digestive system

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and the chemical breakdown by digestive enzymes, that takes place in the mouth. Saliva contains the digestive enzymes amylase, and lingual lipase, secreted...

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Gastric acid

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acid plays a key role in the digestion of proteins by activating digestive enzymes, which together break down the long chains of amino acids of proteins...

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Pancreas

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which neutralizes acid entering the duodenum from the stomach; and digestive enzymes, which break down carbohydrates, proteins and fats in food entering...

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Digestion

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of food into smaller pieces which can subsequently be accessed by digestive enzymes. Mechanical digestion takes place in the mouth through mastication...

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Extracellular digestion

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organisms digest their food extracellularly, within a digestive cavity. In this case the digestive enzymes are released into a cavity that is continuous with...

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Gastrointestinal physiology

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that of digestive enzymes that are secreted in the mouth, stomach and intestines. Some of these enzymes are secreted by accessory digestive organs, while...

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Cholecystokinin

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segment of the small intestine. Its presence causes the release of digestive enzymes and bile from the pancreas and gallbladder, respectively, and also...

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Chymotrypsin

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quimotrase, alpha-chymar, alpha-chymotrypsin A, alpha-chymotrypsin) is a digestive enzyme component of pancreatic juice acting in the duodenum, where it performs...

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Enzyme

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John Howard Northrop and Wendell Meredith Stanley, who worked on the digestive enzymes pepsin (1930), trypsin and chymotrypsin. These three scientists were...

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Gastrointestinal tract

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together with pancreatic juice containing digestive enzymes and bile from the gall bladder. The digestive enzymes break down proteins, and bile emulsifies...

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Exocrine pancreatic insufficiency

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the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas. EPI can occur in humans and is prevalent in...

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Dietary fiber

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plant-derived food that cannot be completely broken down by human digestive enzymes. Dietary fibers are diverse in chemical composition, and can be grouped...

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Oral administration

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reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications...

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Pinguicula

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observed in the sundews). The droplets secrete limited amounts of digestive enzymes, and serve mainly to entrap insects. On contact with an insect, the...

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Carnivorous plant

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of a single species, Heliamphora tatei, which does produce digestive enzymes. The enzymes digest the proteins and nucleic acids in the prey, releasing...

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Pepsi

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"Pepsi" may have been a reference to the drink aiding digestion like the digestive enzyme pepsin, but pepsin itself was never used as an ingredient to Pepsi-Cola...

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Regulatory enzyme

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activated by proteolysis for big reasons: Powerful hydrolytic enzymes, for instance, digestive enzymes, are activated by proteolysis so we can ensure that they...

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Exoenzyme

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with both sources of the enzyme required for complete starch hydrolysis. Lipoprotein lipase (LPL) is a type of digestive enzyme that helps regulate the...

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Diaphonization

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transparent and is achieved by bathing the specimens in a soup of trypsin, a digestive enzyme that slowly breaks down flesh. The dyes alizarin red and alcian blue...

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Small intestine

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the stomach, together with digestive juices from the pancreas (digestive enzymes) and the liver (bile). The digestive enzymes break down proteins and bile...

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Arachnid

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Arachnids produce digestive enzymes in their stomachs, and use their pedipalps and chelicerae to pour them over their dead prey. The digestive juices rapidly...

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Stomach

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stomach a chemical breakdown of food takes place by means of secreted digestive enzymes and gastric acid. The stomach is located between the esophagus and...

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Heterocrine gland

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(testicles and ovaries), pancreas and salivary glands. Pancreas releases digestive enzymes into the small intestine via ducts (exocrine) and secretes insulin...

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Ruminant

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through the digestive tract. Vertebrates lack the ability to hydrolyse the beta [1–4] glycosidic bond of plant cellulose due to the lack of the enzyme cellulase...

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Maltotriose

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glycosidic bonds. It is most commonly produced by the digestive enzyme alpha-amylase (a common enzyme in human saliva) on amylose in starch. The creation...

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Pancreatitis

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pancreas. The pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. There are two main types: acute pancreatitis...

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Mountain papaya

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enzyme present in the milky latex of immature fruits and leaves is often used in the culinary industry as a meat tenderizer since it is a digestive enzyme...

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