The Gs alpha subunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase. Gsα is a GTPase that functions as a cellular signaling protein.
Gsα is the founding member of one of the four families of heterotrimeric G proteins, defined by the alpha subunits they contain: the Gαs family, Gαi/Gαo family, Gαq family, and Gα12/Gα13 family.[5] The Gs-family has only two members: the other member is Golf, named for its predominant expression in the olfactory system. In humans, Gsα is encoded by the GNAS complex locus, while Golfα is encoded by the GNAL gene.
^ abcGRCh38: Ensembl release 89: ENSG00000087460 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027523 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ellis C, Nature Reviews Drug Discovery GPCR Questionnaire Participants (July 2004). "The state of GPCR research in 2004". Nature Reviews. Drug Discovery. 3 (7): 575, 577–626. doi:10.1038/nrd1458. PMID 15272499. S2CID 33620092.
The Gsalphasubunit (Gαs, Gsα) is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase...
Gq protein alphasubunit is a family of heterotrimeric G protein alphasubunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15...
Gi protein alphasubunit is a family of heterotrimeric G protein alphasubunits. This family is also commonly called the Gi/o (Gi /Go ) family or Gi/o/z/t...
the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gsalphasubunit family that is a key component of G protein-coupled receptor-regulated...
Sandwich Islands (ISO country code GS), a British Overseas Territory in the southern Atlantic Ocean Gsalphasubunit, a subtype of G-protein coupled receptors...
class of complexes is made up of alpha (Gα), beta (Gβ) and gamma (Gγ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex...
and activate, i.e. those containing the Gsalphasubunit, Gi alphasubunit, Gq alphasubunit and/or G12 subunit; and f) signaling pathways which they regulate...
pathogenesis has been linked to dysfunctional G proteins (in particular, Gsalphasubunit). Pseudohypoparathyroidism is a very rare disorder, with estimated...
H2 receptors are positively coupled to adenylate cyclase via Gsalphasubunit. It is a potent stimulant of cAMP production, which leads to activation of...
extracellular ligand site on the receptor, the Gsalphasubunit is activated. Activation of the Gsalphasubunit prompts activation of the enzyme adenylate...
the G-protein by exchanging the GDP on the alphasubunit to GTP. The binding of GTP to the alphasubunit results in a structural change and its dissociation...
intracellular heterotrimeric G protein complex by protein domain dynamics. The Gsalphasubunit of the stimulated G protein complex exchanges GDP for GTP in a reaction...
receptor is a G-protein-coupled receptor with Gsalphasubunit as its main communication method. By signaling Gs, adenylyl cyclase is recruited to activate...
They may have KRAS gene mutations (40–65% of cases) and in the GNAS Gsalphasubunit and RNF43, affecting the Wnt signaling pathway. Even if removed surgically...
exposes its active site, allowing it to permanently ribosylate the Gsalphasubunit of the heterotrimeric G protein. This results in constitutive cAMP...
catalyses ADP-ribosylation of the Gsalphasubunit (Gαs) proteins using NAD. The ADP-ribosylation causes the Gαs subunit to lose its catalytic activity of...
locus in humans. Its main product is the heterotrimeric G-protein alphasubunitGs-α, a key component of G protein-coupled receptor-regulated adenylyl...
receptor is a G-protein-coupled receptor with the Gsalphasubunit as its main signaling protein. The subunit dissociates from the receptor when activated...
subunitalpha, mitochondrial also known as hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit...
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