positive regulation of cell population proliferation
MAPK cascade
signal transduction
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of protein kinase B signaling
membrane organization
intracellular signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7039
21802
Ensembl
ENSG00000163235
ENSMUSG00000029999
UniProt
P01135
P48030
RefSeq (mRNA)
NM_001099691 NM_001308158 NM_001308159 NM_003236
NM_031199
RefSeq (protein)
NP_001093161 NP_001295087 NP_001295088 NP_003227
NP_112476 NP_001390047
Location (UCSC)
Chr 2: 70.45 – 70.55 Mb
Chr 6: 86.17 – 86.25 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene.[5] As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic polypeptide.[6] The protein becomes activated when binding to receptors capable of protein kinase activity for cellular signaling.
TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000163235 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029999 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ojeda SR, Ma YJ, Rage F (September 1997). "The transforming growth factor alpha gene family is involved in the neuroendocrine control of mammalian puberty". Molecular Psychiatry. 2 (5): 355–358. doi:10.1038/sj.mp.4000307. PMID 9322223. S2CID 20268790.
growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family, TGF-α is a mitogenic...
(TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β...
Okada M, Ohmura E, Kamiya Y, et al. (1991). "Transforming growth factor (TGF)-alpha in human milk". Life Sciences. 48 (12): 1151–1156. doi:10.1016/0024-3205(91)90452-H...
and other functions in many cell types. TGF-β acts synergistically with transforming growth factor-alpha (TGF-α) in inducing transformation. It also acts...
al. (1990) to describe a possible way of signal transduction between TGFalpha and EGFR. In this type of signaling, specific membrane-bound ligands bind...
life. It is maintained as a stem cell layer through an autocrine signal, TGFalpha, and through paracrine signaling from FGF7 (keratinocyte growth factor)...
Transforming growth factor beta (TGF-β) is a potent cell regulatory polypeptide homodimer of 25kD. It is a multifunctional signaling molecule with more...
TGF beta receptor 2 has been shown to interact with: AP2B1, Cyclin B2, Endoglin, Heat shock protein 90kDa alpha (cytosolic), member A1 STRAP, TGF beta...
affinity for both homodimeric TGFβ1 and TGFβ2 and in addition the heterodimer TGF-β1.2. The TGFβ receptors also bind TGFβ3. TGFβ superfamily receptor TGFβ...
as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation. Studies have shown that ACTA2 is associated with TGF-β pathway...
paraneoplastic effects, such as via the secretion of Prostaglandin E, TGF-alpha, TGF-beta, TNF, and interleukins to increase bone resorption. The destruction...
JS, Rifkin DB (June 2004). "Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1". The Journal of...
ligands, including epidermal growth factor and transforming growth factor alpha (TGF-α). ErbB2 has no known direct activating ligand, and may be in an activated...
Integrins are dimeric cell-surface receptors composed of alpha and beta subunits, which activates TGF-β.< TGF-β is a multifunctional cytokine that modulates a...
cytoprotective PG2 cytoprotective ECF helps gut maturation TGF-alpha promotes the growth of epithelial tissue TGF-beta Il-10 (a cytokine) TGF-alpha; RI,RII...
of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction". Eur. J...
P, Bai ZP (April 2008). "Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne" (PDF). Toxicol...
Agency, an executive agency of Tanzania that provides VIP flight service TGFalpha, a human protein This disambiguation page lists articles associated with...
Szondy Z, Pallai A (January 2017). "Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting...
hormones and hormone-like polypeptides, such as epidermal growth factor and TGFalpha, from transmembrane precursors. After the N-terminal signal peptide is...
"Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta". Mol Reprod Dev. 41 (2): 133–9. doi:10.1002/mrd.1080410203....
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