positive regulation of glucose transmembrane transport
response to carbohydrate
triglyceride homeostasis
signal transduction
response to acidic pH
endocrine pancreas development
positive regulation of insulin secretion
long-term potentiation
regulation of signaling receptor activity
G protein-coupled receptor signaling pathway
regulation of fatty acid biosynthetic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2695
14607
Ensembl
ENSG00000159224
ENSMUSG00000014351
UniProt
P09681
P48756
RefSeq (mRNA)
NM_004123
NM_008119
RefSeq (protein)
NP_004114
NP_032145
Location (UCSC)
Chr 17: 48.96 – 48.97 Mb
Chr 11: 95.92 – 95.92 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Gastric inhibitory polypeptide(GIP), also known as glucose-dependent insulinotropic polypeptide, is an inhibiting hormone of the secretin family of hormones.[5] While it is a weak inhibitor of gastric acid secretion, its main role, being an incretin, is to stimulate insulin secretion.[6]
GIP, along with glucagon-like peptide-1 (GLP-1), belongs to a class of molecules referred to as incretins,[7] which stimulate insulin release on oral food intake.
^ abcGRCh38: Ensembl release 89: ENSG00000159224 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000014351 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Meier JJ, Nauck MA (2005). "Glucagon-like peptide 1(GLP-1) in biology and pathology". Diabetes/Metabolism Research and Reviews. 21 (2): 91–117. doi:10.1002/dmrr.538. PMID 15759282. S2CID 39547553.
^Pederson RA, McIntosh CH (2016). "Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections". Journal of Diabetes Investigation. 7 (Suppl 1): 4–7. doi:10.1111/jdi.12480. PMC 4854497. PMID 27186348.
^Efendic S, Portwood N (2004). "Overview of incretin hormones". Hormone and Metabolic Research. 36 (11–12): 742–6. doi:10.1055/s-2004-826157. PMID 15655702. S2CID 11634548.
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