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GATA zinc finger information


GATA zinc finger
zinc fingers as protein recognition motifs: structural basis for the gata-1/friend of gata interaction
Identifiers
SymbolGATA
PfamPF00320
Pfam clanCL0167
InterProIPR000679
PROSITEPDOC00300
SCOP21gat / SCOPe / SUPFAM
CDDcd00202
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, GATA zinc fingers are zinc-containing domains found in a number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins). Some members of this class of zinc fingers specifically bind the DNA sequence (A/T)GATA(A/G) in the regulatory regions of genes.,[1] giving rise to the name of the domain. In these domains, a single zinc ion is coordinated by 4 cysteine residues.[2][3] NMR studies have shown the core of the Znf to comprise 2 irregular anti-parallel beta-sheets and an alpha-helix, followed by a long loop to the C-terminal end of the finger. The N-terminal part, which includes the helix, is similar in structure, but not sequence, to the N-terminal zinc module of the glucocorticoid receptor DNA-binding domain. The helix and the loop connecting the 2 beta-sheets interact with the major groove of the DNA, while the C-terminal tail wraps around into the minor groove. Interactions between the Znf and DNA are mainly hydrophobic, explaining the preponderance of thymines in the binding site; a large number of interactions with the phosphate backbone have also been observed.[3] Two GATA zinc fingers are found in GATA-family transcription factors. However, there are several proteins that only contain a single copy of the domain. It is also worth noting that many GATA-type Znfs (such as those found in the proteins GATAD2B and MTA1) have not been experimentally demonstrated to be DNA-binding domains. Furthermore, several GATA-type Znfs have been demonstrated to act as protein-recognition domains. For example, the N-terminal Znf of GATA1 binds specifically to a zinc finger from the transcriptional coregulator FOG1 (ZFPM1).[4]

  1. ^ Yamamoto M, Ko LJ, Leonard MW, Beug H, Orkin SH, Engel JD (October 1990). "Activity and tissue-specific expression of the transcription factor NF-E1 multigene family". Genes Dev. 4 (10): 1650–62. doi:10.1101/gad.4.10.1650. PMID 2249770.
  2. ^ Evans T, Felsenfeld G (September 1989). "The erythroid-specific transcription factor Eryf1: a new finger protein". Cell. 58 (5): 877–85. doi:10.1016/0092-8674(89)90940-9. PMID 2776214. S2CID 46374550.
  3. ^ a b Omichinski JG, Clore GM, Schaad O, Felsenfeld G, Trainor C, Appella E, Stahl SJ, Gronenborn AM (July 1993). "NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1". Science. 261 (5120): 438–46. Bibcode:1993Sci...261..438O. doi:10.1126/science.8332909. PMID 8332909.
  4. ^ Liew CK, Simpson RJ, Kwan AH, Crofts LA, Loughlin FE, Matthews JM, Crossley M, Mackay JP (March 2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction". PNAS USA. 102 (3): 583–8. Bibcode:2005PNAS..102..583L. doi:10.1073/pnas.0407511102. PMC 545545. PMID 15644435.

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GATA zinc finger

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TAZ zinc finger

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Zinc finger protein ZFPM1

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Zinc finger protein ZFPM1 also known as friend of GATA protein 1 (FOG-1) is a protein that in humans is encoded by the ZFPM1 gene. It is a cofactor of...

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ZFPM2

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Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein...

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GFI1B

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Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene. GRCh38: Ensembl release 89: ENSG00000165702 – Ensembl, May 2017 GRCm38:...

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and GATA1-S, C-ZnF (i.e. C-terminus zinc finger) binds to DNA-specific nucleic acid sequences sites viz., (T/A(GATA)A/G), on the expression-regulating...

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22.2.536-546.2002. PMC 139742. PMID 11756549. "Entrez Gene: GATAD2B GATA zinc finger domain containing 2B". Brackertz M, Boeke Joern, Zhang Ru, Renkawitz...

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Zinc finger protein 165 is a protein that in humans is encoded by the ZNF165 gene. This gene encodes a member of the Kruppel family of zinc finger proteins...

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ZEB1

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Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) encodes a zinc finger and...

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Zinc finger protein 804A

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Zinc finger protein 804A is a protein that in humans is encoded by the ZNF804A gene. The human gene maps to chromosome 2 q32.1 and consists of 4 exons...

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GLI1

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Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated...

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GATA3

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promoters. The other zinc finger, ZNF1, is at the protein's N-terminus and interacts with various nuclear factors, including Zinc finger protein 1 (i.e. ZFPM1...

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ZCCHC18

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Zinc finger CCHC-type containing 18 (ZCCHC18) is a protein that in humans is encoded by ZCCHC18 gene. It is also known as Smad-interacting zinc finger...

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EGR1

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EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein...

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ZBTB32

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seems to interact Zinc finger and BTB domain-containing protein 16 (Zbtb16) Zinc-finger elbow-related proline domain protein 2 (Zpo2) GATA binding protein...

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ZNF3

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Zinc finger protein 3 is a protein that in humans is encoded by the ZNF3 gene. Zinc finger GRCh38: Ensembl release 89: ENSG00000166526 – Ensembl, May 2017...

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Pioneer factor

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NF-Y) and other transcription factors that use zinc finger(s) for DNA binding (Groucho TLE, Gal4, and GATA). The eukaryotic cell condenses its genome into...

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IKZF1

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DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros is a transcription...

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been linked with pancreatic agenesis and congenital heart defects. GATA-6, a zinc finger transcription factor, is important in the endodermal differentiation...

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Tsuzuki S, Enver T (May 2002). "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated...

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Haematopoiesis

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six zinc fingers domains, four are conserved DNA-binding domain and two are for dimerization. Very important finding is, that different zinc fingers are...

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