ZBTB32 information

ZBTB32
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3M5B
Identifiers
Aliases	ZBTB32, FAXF, FAZF, Rog, TZFP, ZNF538, zinc finger and BTB domain containing 32
External IDs	OMIM: 605859; MGI: 1891838; HomoloGene: 8661; GeneCards: ZBTB32; OMA:ZBTB32 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,717,038 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,298,334 bp
RNA expression pattern
	Top expressed in
	testicle; ; left testis; ; right testis; ; gonad; ; spleen; ; lymph node; ; right uterine tube; ; sural nerve; ; appendix; ; granulocyte;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; zygote; ; embryo; ; embryo; ; secondary oocyte; ; primary oocyte; ; blastocyst; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; DNA binding; zinc ion binding; protein binding; transcription corepressor activity; metal ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	27033
	58206
	ENSG00000011590
	ENSMUSG00000006310
	Q9Y2Y4
	Q9JKD9
	NM_014383; NM_001316902; NM_001316903
	NM_021397
	NP_001303831; NP_001303832; NP_055198
	NP_067372
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain-containing protein 32 is a protein that in humans is encoded by the 1960 bp ZBTB32 gene. The 52 kDa protein (487 aa) is a transcriptional repressor and the gene is expressed in T and B cells upon activation, but also significantly in testis cells. It is a member of the Poxviruses and Zinc-finger (POZ) and Krüppel (POK) family of proteins,^[5]^[6] and was identified in multiple screens involving either immune cell tumorigenesis or immune cell development.

The protein recruits histone modification enzymes to chromatin to affect gene activation.^[7] ZBTB32 recruits corepressors, such as N-CoR and HDACs to its target genes, induces repressive chromatin states and acts cooperatively with other proteins, e.g. with Blimp-1,^[7] to suppress the transcription of genes .^[7]

It contains a N-terminal BTB/POZ domain (IPR000210) or a SKP1/BTB/POZ domain (IPR011333), and three C-terminal zinc fingers, Znf_C2H2_sf. (IPR036236), Znf_C2H2_type domain (IPR013087), a Znf_RING/FYVE/PHD domain (IPR013083), followed by a putative UBZ4 domain.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011590 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (December 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. doi:10.1182/blood.V94.11.3737. PMID 10572087.
^ "Entrez Gene: ZBTB32 zinc finger and BTB domain containing 32".
^ ^a ^b ^c Yoon HS, Scharer CD, Majumder P, Davis CW, Butler R, Zinzow-Kramer W, Skountzou I, Koutsonanos DG, Ahmed R, Boss JM (2012). "ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells". Journal of Immunology. 189 (5): 2393–403. doi:10.4049/jimmunol.1103371. PMC 3424359. PMID 22851713.
^ Rizzo AA, Salerno PE, Bezsonova I, Korzhnev DM (September 2014). "NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response". Biochemistry. 53 (37): 5895–906. doi:10.1021/bi500823h. PMID 25162118.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011590 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006310 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10572087-5] Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD (December 1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. doi:10.1182/blood.V94.11.3737. PMID 10572087.

[entrez-6] "Entrez Gene: ZBTB32 zinc finger and BTB domain containing 32".

[Yoon_2012-7] Yoon HS, Scharer CD, Majumder P, Davis CW, Butler R, Zinzow-Kramer W, Skountzou I, Koutsonanos DG, Ahmed R, Boss JM (2012). "ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells". Journal of Immunology. 189 (5): 2393–403. doi:10.4049/jimmunol.1103371. PMC 3424359. PMID 22851713.

[pmid25162118-8] Rizzo AA, Salerno PE, Bezsonova I, Korzhnev DM (September 2014). "NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response". Biochemistry. 53 (37): 5895–906. doi:10.1021/bi500823h. PMID 25162118.

ZBTB32 information

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