negative regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
negative regulation of transforming growth factor beta2 production
tube morphogenesis
negative regulation of apoptotic process
smooth muscle cell differentiation
transcription, DNA-templated
positive regulation of angiogenesis
outflow tract septum morphogenesis
response to estrogen
animal organ formation
positive regulation of cardiac muscle cell proliferation
cardiac muscle hypertrophy in response to stress
intestinal epithelial cell differentiation
positive regulation of BMP signaling pathway
positive regulation of cardioblast differentiation
regulation of gene expression
phospholipid metabolic process
liver development
pancreas development
response to growth factor
type II pneumocyte differentiation
lung saccule development
negative regulation of transcription, DNA-templated
cellular response to hypoxia
type B pancreatic cell differentiation
cellular response to gonadotropin stimulus
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
positive regulation of cardiac muscle myoblast proliferation
heart development
animal organ morphogenesis
tissue development
cell development
anatomical structure formation involved in morphogenesis
digestive tract development
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2627
14465
Ensembl
ENSG00000141448
ENSMUSG00000005836
UniProt
Q92908
Q61169
RefSeq (mRNA)
NM_005257
NM_010258
RefSeq (protein)
NP_005248
NP_034388
Location (UCSC)
Chr 18: 22.17 – 22.2 Mb
Chr 18: 11.05 – 11.09 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene.[5] The gene product preferentially binds (A/T/C)GAT(A/T)(A) of the consensus binding sequence.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000141448 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000005836 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: GATA6 GATA binding protein 6".
^Sakai Y, Nakagawa R, Sato R, Maeda M (1998). "Selection of DNA binding sites for human transcriptional regulator GATA-6". Biochem Biophys Res Commun. 250 (3): 682–688. doi:10.1006/bbrc.1998.9374. PMID 9784406.
GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 gene. The gene product preferentially binds (A/T/C)GAT(A/T)(A)...
regulatory factors, including MyoD, Myf5, myogenin, and MRF4. GATA4 and GATA6 also play a role in myocyte differentiation. Skeletal muscle fibers are...
adenocarcinoma and had frequent amplifications in ERBB2, VEGFA, GATA4, and GATA6 Ovarian Serous Cystadenocarcinoma 489 Mutations in TP53 occurred in 96%...
Elf3 coactivator in differentiation of absorptive enterocytes 19801644 GATA6 Regulates proximal-distal identity in the intestines 21262227 GATA4 Required...
(anomaly) was also observed when GATA6 was inactivated within vascular smooth muscle cells. GATA6 in combination with Wnt (Wnt2-GATA6) plays a role in the development...
protein interacts primarily with the GATA4 but also with GATA2, GATA5, and GATA6 transcription factors. ZFPM2 protein's interaction with GATA4 is notable...
Brian (2014-03-01). "Whole exome sequencing identifies de novo mutations in GATA6 associated with congenital diaphragmatic hernia". Journal of Medical Genetics...
(see also GATA3) GATA4 (see also GATA4) GATA5 (see also GATA5) GATA6 (see also GATA6) In yeast: GLN3 (see also GLN3) GAT1 (see also GAT1) DAL80 (see...
rarer. Genetic changes that disable the transcription factors CNOT1, GATA4, GATA6, PDX1, PTF1A, or RFX6 – all involved in the development of the pancreas...
so far, including humans and mice, express 6 GATA genes, GATA1 through GATA6. The human GATA2 gene is located on the long (or "q") arm of chromosome...
so far, including humans and mice, express 6 GATA genes, GATA1 through GATA6. The human GATA2 gene is located on the long (or "q") arm of chromosome...
2008.78. PMID 18949017. Kodo K, Nishizawa T, Furutani M, et al. (2009). "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin...
highly conserved T-elements to activate the promoters of Eomes, T, Sox17 and Gata6, which are factors essential for mesoderm differentiation and extra embryonic...