positive regulation of smoothened signaling pathway
lung development
positive regulation of cell migration
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
notochord regression
transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of DNA replication
ventral midline development
multicellular organism development
regulation of smoothened signaling pathway
liver regeneration
response to wounding
regulation of osteoblast differentiation
osteoblast differentiation
spermatogenesis
positive regulation of cell population proliferation
cerebellar cortex morphogenesis
regulation of hepatocyte proliferation
canonical Wnt signaling pathway
smoothened signaling pathway
dorsal/ventral pattern formation
negative regulation of canonical Wnt signaling pathway
positive regulation of transcription by RNA polymerase II
digestive tract morphogenesis
prostate gland development
positive regulation of cardiac muscle cell proliferation
positive regulation of cell cycle G1/S phase transition
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2735
14632
Ensembl
ENSG00000111087
ENSMUSG00000025407
UniProt
P08151
P47806
RefSeq (mRNA)
NM_001160045 NM_001167609 NM_005269
NM_010296
RefSeq (protein)
NP_001153517 NP_001161081 NP_005260
NP_034426
Location (UCSC)
Chr 12: 57.46 – 57.47 Mb
Chr 10: 127.17 – 127.18 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000111087 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025407 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, Wong AJ, Vogelstein B (April 1987). "Identification of an amplified, highly expressed gene in a human glioma". Science. 236 (4797): 70–3. Bibcode:1987Sci...236...70K. doi:10.1126/science.3563490. PMID 3563490.
Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from...
overexpression of Gli1 (Jacob and Briscoe, 2003). Gli1 has been shown to induce the two GLI2 α/β isoforms. Transgenic double homozygous Gli1-/- and Gli2-/-...
copy-number alterations that contribute to increased conversion of the oncogenes Gli1–3 into transcriptional activators by the Hedgehog signaling pathway are included...
different Gli proteins are present, viz. Gli1, Gli2 and Gli3, which are expressed in the neural tube. Mice mutants for Gli1 show normal spinal cord development...
Greyhound Lines, a North-American bus carrier Volkswagen GLI, an automobile GLI1, GLI2, GLI3, glioma-associated family of transcription factors This disambiguation...
activation of Shh-GLI1 cascades is caused by STIL's interaction with SUFU, which prevents SUFU from acting as a repressor of GLI1. Normally, GLI1 binds to the...
activation of the GLI transcription factors (Process "5"): the activators Gli1 and Gli2 and the repressor Gli3. The sequence of molecular events that connect...
- a fusion between the MALAT1 and GLI1 genes - has been described. This fusion causes over expression of the GLI1 protein and activation of the Sonic...
activation of genes. GANT-61 effectively reduced the DNA-binding affinity of GLI1 and GLI2 in multiple cancer cell lines, including rhabdomyosarcoma, osteosarcoma...
allowing the cell to abruptly switch states at precise Shh concentrations. gli1 and gli2 transcription is activated by Shh, and their gene products act as...
PMID 11311120. Mao J, Maye P, Kogerman P, et al. (2002). "Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1". J. Biol. Chem. 277 (38):...
SHH inhibits the Smoothened receptor. Activated smoothened in turn causes Gli1, Gli2, and Gli3 to be translocated into the nucleus where they activate target...
complex that recognizes H3K27me3. This occurs in a Gli-dependent manner, as Gli1 and Gli2 are downstream effectors of the Hedgehog signaling pathway. In culture...
Hedgehog signaling pathway. SMO inhibition causes the transcription factors GLI1 and GLI2 to remain inactive, which prevents the expression of tumor mediating...
Gendron P, Romeo AA, Morris SJ, et al. (July 2014). "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507):...
which a translocational mutation causes the fusion of the ACTB gene over GLI1 in Chromosome 12. Juvenile onset dystonia is a rare degenerative disease...
part of the hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and hedgehog target genes cannot be transcribed...
Koga K, Nakashima H, Yao T, Tsuneyoshi M, Tanaka M, Katano M (July 2006). "Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer...
Smoothened, leading to activation of the Gli family of transcription factors (GLI1, GLI2, and GLI3). In this context Shh acts as a morphogen - it induces cell...
pathway. There are three Gli factors that are essential for limb development: Gli1, Gli2 and Gli3. Without Shh, Gli2 and Gli3 are processed to a repressor form...
different actions. For example, one study showed that there are proteins called Gli1, Gli2, and Gli3 that affect ventral hindbrain development, and are also required...
Nakafuku M, Ishii S (March 1999). "Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3". The Journal of Biological Chemistry. 274 (12):...
Philpott MP, Quinn AG (15 August 2002). "FOXM1 is a downstream target of Gli1 in basal cell carcinomas". Cancer Res. 62 (16): 4773–80. PMID 12183437. Kalinichenko...
tumor-promoting function in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling". World Journal of Gastroenterology. 25 (8): 923–940. doi:10.3748/wjg...
result in the Dandy–Walker malformation. ZIC1 has been shown to interact with GLI1 and GLI3. GRCh38: Ensembl release 89: ENSG00000152977 – Ensembl, May 2017...
Becker, Michael W.; Pei, Shanshan (2014-07-03). "The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation". Nature. 511 (7507):...
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