ZCCHC18 information

ZCCHC18
Identifiers
Aliases	ZCCHC18, PNMA7B, SIZN2, zinc finger CCHC-type containing 18
External IDs	MGI: 1914245; HomoloGene: 121722; GeneCards: ZCCHC18; OMA:ZCCHC18 - orthologs
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	135,899,221 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; ganglionic eminence; ; popliteal artery; ; hypothalamus; ; cerebellar hemisphere; ; islet of Langerhans; ; Brodmann area 9; ; nucleus accumbens;
	Top expressed in
	ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; nucleus accumbens; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; central gray substance of midbrain; ; anterior amygdaloid area; ; nucleus of stria terminalis; ; arcuate nucleus; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nuclear receptor coactivator activity; metal ion binding;
Cellular component	nuclear speck;
Biological process	BMP signaling pathway; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	644353
	66995
	n/a
	ENSMUSG00000031428
	P0CG32
	Q8VD24
	NM_001143978
NM_001035509; NM_001035510; NM_025893; NM_001358437; NM_001358439;
	NM_001358440; NM_001358441
	NP_001137450
NP_001030586; NP_001030587; NP_080169; NP_001345366; NP_001345368;
	NP_001345369; NP_001345370
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger CCHC-type containing 18 (ZCCHC18) is a protein that in humans is encoded by ZCCHC18 gene. It is also known as Smad-interacting zinc finger protein 2 (SIZN2), para-neoplastic Ma antigen family member 7b (PNMA7B), and LOC644353.^[4]^[5] Other names such as zinc finger, CCHC domain containing 12 pseudogene 1, P0CG32, ZCC18_HUMAN had been used to describe this protein.

ZCCHC18 belongs to the ZCCHC12 family or para-neoplastic Ma (PNMA). It is a ligand-dependent nuclear receptor transcription coactivator. Its zinc finger domain is CCHC which binds to zinc ion (see protein section for detail information on CCHC motif).^[6]

It is worthwhile to mention that in mammals, PNMA is derived from Ty3/Gypsy long terminal repeat (LTR) retrotransposons and PNMA family encodes the Gag-like protein.^[7] Although the full functions remain unknown, most PNMA genes are expressed in brains of macaques and mice.^[8] PNMA1, 2 and 3 were found in the serum of patients with paraneoplastic neurological disorders. The family also includes modulator of apoptosis 1, having a role in death receptor-dependent apoptosis.^[9]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031428 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ZCCHC18 Gene". GeneCards.
^ "Gene: ZCCHC18 (ENSG00000166707) - Summary - Homo sapiens - Ensembl genome browser 91". useast.ensembl.org. Retrieved 2018-02-22.
^ "Human Gene ZCCHC18 (ENST00000611638.4) Description and Page Index". genome.ucsc.edu. Retrieved 2018-04-30.
^ Summers MF (January 1991). "Zinc finger motif for single-stranded nucleic acids? Investigations by nuclear magnetic resonance". Journal of Cellular Biochemistry. 45 (1): 41–8. doi:10.1002/jcb.240450110. PMID 2005183. S2CID 45192514.
^ Takaji M, Komatsu Y, Watakabe A, Hashikawa T, Yamamori T (December 2009). "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner". Cerebral Cortex. 19 (12): 2865–79. doi:10.1093/cercor/bhp062. PMC 2774394. PMID 19366867.
^ Iwasaki S, Suzuki S, Pelekanos M, Clark H, Ono R, Shaw G, Renfree MB, Kaneko-Ishino T, Ishino F (October 2013). "Identification of a novel PNMA-MS1 gene in marsupials suggests the LTR retrotransposon-derived PNMA genes evolved differently in marsupials and eutherians". DNA Research. 20 (5): 425–36. doi:10.1093/dnares/dst020. PMC 3789554. PMID 23704700.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031428 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "ZCCHC18 Gene". GeneCards.

[5] "Gene: ZCCHC18 (ENSG00000166707) - Summary - Homo sapiens - Ensembl genome browser 91". useast.ensembl.org. Retrieved 2018-02-22.

[:0-6] "Human Gene ZCCHC18 (ENST00000611638.4) Description and Page Index". genome.ucsc.edu. Retrieved 2018-04-30.

[ReferenceA-7] Summers MF (January 1991). "Zinc finger motif for single-stranded nucleic acids? Investigations by nuclear magnetic resonance". Journal of Cellular Biochemistry. 45 (1): 41–8. doi:10.1002/jcb.240450110. PMID 2005183. S2CID 45192514.

[8] Takaji M, Komatsu Y, Watakabe A, Hashikawa T, Yamamori T (December 2009). "Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner". Cerebral Cortex. 19 (12): 2865–79. doi:10.1093/cercor/bhp062. PMC 2774394. PMID 19366867.

[9] Iwasaki S, Suzuki S, Pelekanos M, Clark H, Ono R, Shaw G, Renfree MB, Kaneko-Ishino T, Ishino F (October 2013). "Identification of a novel PNMA-MS1 gene in marsupials suggests the LTR retrotransposon-derived PNMA genes evolved differently in marsupials and eutherians". DNA Research. 20 (5): 425–36. doi:10.1093/dnares/dst020. PMC 3789554. PMID 23704700.