GATA3 information

GATA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HC7, 4HC9, 4HCA
Identifiers
Aliases	GATA3, HDR, HDRS, GATA binding protein 3
External IDs	OMIM: 131320; MGI: 95663; HomoloGene: 1550; GeneCards: GATA3; OMA:GATA3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	8,075,198 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	9,894,845 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; nipple; ; skin of arm; ; lactiferous duct; ; renal medulla; ; seminal vesicula; ; skin of abdomen; ; vulva; ; corpus epididymis;
	Top expressed in
	transitional epithelium of urinary bladder; ; hair follicle; ; medullary collecting duct; ; seminal vesicula; ; adrenal medulla; ; lactiferous gland; ; skin of back; ; nasal cavity; ; skin of external ear; ; lip;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding; HMG box domain binding; chromatin binding; metal ion binding; DNA binding; cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; interleukin-2 receptor binding; core promoter sequence-specific DNA binding; transcription cis-regulatory region binding; protein dimerization activity; E-box binding; protein binding; zinc ion binding; transcription factor binding; transcription coactivator activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coregulator activity;
Cellular component	nucleus; transcription regulator complex; nucleoplasm;
Biological process	negative regulation of cell population proliferation; regulation of establishment of cell polarity; ureteric bud formation; negative regulation of cell cycle; thymic T cell selection; response to ethanol; positive regulation of T cell differentiation; erythrocyte differentiation; inner ear morphogenesis; cell maturation; regulation of histone H3-K27 methylation; cardiac right ventricle morphogenesis; phosphatidylinositol 3-kinase signaling; norepinephrine biosynthetic process; ear development; homeostasis of number of cells; sympathetic nervous system development; T-helper 2 cell differentiation; regulation of cellular response to X-ray; cell fate determination; post-embryonic development; cellular response to BMP stimulus; mesonephros development; neuron differentiation; regulation of neuron apoptotic process; signal transduction; cellular response to cytokine stimulus; cellular response to interleukin-4; T cell receptor signaling pathway; neuron migration; positive regulation of interleukin-5 production; regulation of CD4-positive, alpha-beta T cell differentiation; parathyroid gland development; negative regulation of DNA demethylation; positive regulation of interleukin-4 production; negative regulation of mammary gland epithelial cell proliferation; regulation of transcription by RNA polymerase II; thymus development; nervous system development; otic vesicle development; regulation of transcription, DNA-templated; positive regulation of T-helper 2 cell cytokine production; regulation of nephron tubule epithelial cell differentiation; positive regulation of thyroid hormone generation; lymphocyte migration; negative regulation of interleukin-2 production; regulation of neuron projection development; uterus development; axon guidance; mesenchymal to epithelial transition; negative regulation of cell proliferation involved in mesonephros development; aortic valve morphogenesis; cellular response to tumor necrosis factor; negative regulation of fat cell differentiation; anatomical structure morphogenesis; cellular response to interferon-alpha; negative regulation of transcription, DNA-templated; T cell differentiation; response to virus; negative regulation of endothelial cell apoptotic process; innate immune response; canonical Wnt signaling pathway involved in metanephric kidney development; positive regulation of transcription regulatory region DNA binding; positive regulation of endothelial cell migration; positive regulation of interleukin-13 production; in utero embryonic development; negative regulation of interferon-gamma production; humoral immune response; developmental growth; kidney development; positive regulation of ureteric bud formation; positive regulation of gene expression; mast cell differentiation; positive regulation of histone H3-K9 acetylation; positive regulation of cell differentiation; negative regulation of transcription by RNA polymerase II; male gonad development; nephric duct morphogenesis; ventricular septum development; positive regulation of cytokine production; lens development in camera-type eye; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation; transcription, DNA-templated; negative regulation of gene expression; parathyroid hormone secretion; nephric duct formation; immune system process; negative regulation of inflammatory response; pharyngeal system development; embryonic organ development; response to estrogen; blood coagulation; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation; positive regulation of signal transduction; ureter maturation; positive regulation of histone H3-K14 acetylation; positive regulation of transcription, DNA-templated; response to gamma radiation; cell morphogenesis; embryonic hemopoiesis; positive regulation of transcription by RNA polymerase II; negative regulation of cell motility; pro-T cell differentiation; TOR signaling; type IV hypersensitivity; defense response; regulation of histone H3-K4 methylation; renal system development; positive regulation of protein kinase B signaling; cell activation; chromatin remodeling; T cell differentiation in thymus; cochlea development; transcription by RNA polymerase II; protein deubiquitination; anatomical structure formation involved in morphogenesis; regulation of hematopoietic stem cell differentiation; cytokine-mediated signaling pathway; heart development; animal organ morphogenesis; tissue development; cell development; digestive tract development; immune system development; regulation of epithelial cell differentiation; ureter morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2625
	14462
	ENSG00000107485
	ENSMUSG00000015619
	P23771
	P23772
	NM_001002295; NM_002051
	NM_008091; NM_001355110; NM_001355111; NM_001355112
	NP_001002295; NP_002042
	NP_032117; NP_001342039; NP_001342040; NP_001342041
	Wikidata
View/Edit Human	View/Edit Mouse

GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.^[5]^[6]^[7]

The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. GATA3 plays central role in allergy and immunity against worm infections.^[8]^[9] GATA3 haploinsufficiency (i.e. loss of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome.^[10]^[11]^[12]

Current clinical and laboratory research is focusing on determining the benefits of directly or indirectly blocking the action of GATA3 in inflammatory and allergic diseases such as asthma.^[10] It is also proposed to be a clinically important marker for various types of cancer, particularly those of the breast. However, the role, if any, of GATA3 in the development of these cancers is under study and remains unclear.^[13]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015619 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joulin V, Bories D, Eléouet JF, Labastie MC, Chrétien S, Mattéi MG, Roméo PH (Jul 1991). "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family". The EMBO Journal. 10 (7): 1809–16. doi:10.1002/j.1460-2075.1991.tb07706.x. PMC 452855. PMID 2050118.
^ Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T (Jun 2004). "Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci". The Journal of Biological Chemistry. 279 (26): 26983–90. doi:10.1074/jbc.M403688200. PMID 15087456.
^ "Entrez Gene: GATA3 GATA binding protein 3".
^ Zheng Wp, Flavell RA (May 1997). "The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells". Cell. 89 (4): 587–596. doi:10.1016/s0092-8674(00)80240-8. PMID 9160750. S2CID 18342599.
^ Zheng WP, Flavell RA (1 June 2016). "Pillars Article: The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell. 1997. 89: 587-596". Journal of Immunology. 196 (11): 4426–35. PMID 27207805.
^ ^a ^b Barnes PJ (April 2018). "Targeting cytokines to treat asthma and chronic obstructive pulmonary disease". Nature Reviews. Immunology. 18 (7): 454–466. doi:10.1038/s41577-018-0006-6. PMID 29626211. S2CID 4647119.
^ "OMIM Entry - * 131320 - GATA-BINDING PROTEIN 3; GATA3". omim.org.
^ Belge H, Dahan K, Cambier JF, Benoit V, Morelle J, Bloch J, Vanhille P, Pirson Y, Demoulin N (May 2017). "Clinical and mutational spectrum of hypoparathyroidism, deafness and renal dysplasia syndrome". Nephrology, Dialysis, Transplantation. 32 (5): 830–837. doi:10.1093/ndt/gfw271. PMID 27387476.
^ Ordóñez NG (September 2013). "Value of GATA3 immunostaining in tumor diagnosis: a review". Advances in Anatomic Pathology. 20 (5): 352–60. doi:10.1097/PAP.0b013e3182a28a68. PMID 23939152. S2CID 8874053.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107485 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015619 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2050118-5] Joulin V, Bories D, Eléouet JF, Labastie MC, Chrétien S, Mattéi MG, Roméo PH (Jul 1991). "A T-cell specific TCR delta DNA binding protein is a member of the human GATA family". The EMBO Journal. 10 (7): 1809–16. doi:10.1002/j.1460-2075.1991.tb07706.x. PMC 452855. PMID 2050118.

[pmid15087456-6] Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T (Jun 2004). "Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci". The Journal of Biological Chemistry. 279 (26): 26983–90. doi:10.1074/jbc.M403688200. PMID 15087456.

[entrez-7] "Entrez Gene: GATA3 GATA binding protein 3".

[8] Zheng Wp, Flavell RA (May 1997). "The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells". Cell. 89 (4): 587–596. doi:10.1016/s0092-8674(00)80240-8. PMID 9160750. S2CID 18342599.

[9] Zheng WP, Flavell RA (1 June 2016). "Pillars Article: The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. Cell. 1997. 89: 587-596". Journal of Immunology. 196 (11): 4426–35. PMID 27207805.

[pmid29626211-10] Barnes PJ (April 2018). "Targeting cytokines to treat asthma and chronic obstructive pulmonary disease". Nature Reviews. Immunology. 18 (7): 454–466. doi:10.1038/s41577-018-0006-6. PMID 29626211. S2CID 4647119.

[omim.org-11] "OMIM Entry - * 131320 - GATA-BINDING PROTEIN 3; GATA3". omim.org.

[pmid27387476-12] Belge H, Dahan K, Cambier JF, Benoit V, Morelle J, Bloch J, Vanhille P, Pirson Y, Demoulin N (May 2017). "Clinical and mutational spectrum of hypoparathyroidism, deafness and renal dysplasia syndrome". Nephrology, Dialysis, Transplantation. 32 (5): 830–837. doi:10.1093/ndt/gfw271. PMID 27387476.

[pmid23939152-13] Ordóñez NG (September 2013). "Value of GATA3 immunostaining in tumor diagnosis: a review". Advances in Anatomic Pathology. 20 (5): 352–60. doi:10.1097/PAP.0b013e3182a28a68. PMID 23939152. S2CID 8874053.

GATA3 information

and 28 Related for: GATA3 information

GATA3

Regulatory T cell

Barakat syndrome

HDR

Allelic exclusion

T helper cell

GATA transcription factor

Endocrine system

Cluster of differentiation

Acute lymphoblastic leukemia

Innate lymphoid cell

Inflammatory bowel disease

Organ of Corti

Cochlear duct

Kidney cancer

List of human transcription factors

FOXA1

C1orf68

Tetracapsuloides

Chromosome 10

ETS2

Ciliopathy

The Cancer Genome Atlas

Deoxyribozyme

ZBTB32

Interleukin 5

Breast cancer classification

NFAT