Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[5][6][7]
ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[7][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has seven zinc fingers and one homeodomain.[8] The structure of the homeodomain is shown on the right.
^ abcGRCh38: Ensembl release 89: ENSG00000148516 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024238 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
^ abWilliams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. Bibcode:1991Sci...254.1791W. doi:10.1126/science.1840704. PMID 1840704.
E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription...
Chromosome 1 open reading frame 68, or C1orf68, is a human gene which encodes for skin-specific protein 32. C1orf68 gene is expressed in the skin, is a...
specific TF according to literature or domain structure – No motif [1,063] ZEB1 ENSG00000148516 C2H2 ZF; Homeodomain Known motif – In vivo/Misc source [1...
downregulation of transcription factors required for EMT, including Slug, Twist, and Zeb1, and to increased expression of E-cadherin. Several drugs classified as "AXL...
mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression". The Journal of Biological Chemistry. 277 (42): 39209–16. doi:10...
(2014-08-27). Tontonoz, Peter (ed.). "Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network". eLife...
lymph node formation. Biomarkers of VM in prostate cancer include: HIF1α, ZEB1, EphA2, and Sp1. Renal cell carcinoma (RCC) is cancer of the kidneys with...
type 2 is linked to the mutations in COL8A2, and PPCD type 3 mutations in ZEB1 gene, but the underlying genetic disturbance in PPCD type 1 is unknown.[citation...
Hopt U, Keck T, Brabletz S, Brabletz T (December 2009). "The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs". Nature...
transition in epithelial ovarian cancer cells by regulation of GSK-3β/β-catenin/ZEB1 signaling pathway". Oncology Reports. 35 (4): 2027–2034. doi:10.3892/or.2016...
ZEB2 (previously also known as SMADIP1, SIP1) and its mammalian paralog ZEB1 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain...