ZFPM2 information

ZFPM2
Identifiers
Aliases	ZFPM2, DIH3, FOG2, ZC2HC11B, ZNF89B, hFOG-2, SRXY9, zinc finger protein, FOG family member 2
External IDs	OMIM: 603693; MGI: 1334444; HomoloGene: 8008; GeneCards: ZFPM2; OMA:ZFPM2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	105,804,539 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	40,967,988 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; vastus lateralis muscle; ; triceps brachii muscle; ; pons; ; parietal pleura; ; deltoid muscle; ; cerebellum; ; endothelial cell; ; sural nerve; ; right ventricle;
	Top expressed in
	atrioventricular valve; ; endocardial cushion; ; cerebellar vermis; ; vas deferens; ; belly cord; ; pontine nuclei; ; medullary collecting duct; ; atrium; ; ascending aorta; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; transcription corepressor activity; zinc ion binding; transcription factor binding; metal ion binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; embryonic organ development; lung development; cardiac muscle tissue development; ventricular septum morphogenesis; right ventricular cardiac muscle tissue morphogenesis; blood coagulation; in utero embryonic development; negative regulation of transcription by RNA polymerase II; negative regulation of cell death; transcription, DNA-templated; outflow tract septum morphogenesis; vasculogenesis; positive regulation of transcription, DNA-templated; heart development; negative regulation of female gonad development; gonadal mesoderm development; negative regulation of transcription, DNA-templated; positive regulation of male gonad development; positive regulation of transcription by RNA polymerase II; positive regulation of cardiac muscle cell proliferation; cell differentiation; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	23414
	22762
	ENSG00000169946
	ENSMUSG00000022306
	Q8WW38
	Q8CCH7
	NM_012082; NM_001362836; NM_001362837
	NM_011766; NM_001356998
	NP_036214; NP_001349765; NP_001349766
	NP_035896; NP_001343927
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein ZFPM2, i.e. zinc finger protein, FOG family member 2, but also termed Friend of GATA2, Friend of GATA-2, FOG2, or FOG-2, is a protein that in humans is encoded by the ZFPM2 and in mice by the Zfpm2 gene.^[5]^[6]^[7]

The zinc finger-containing protein encoded by this gene is a widely expressed member of the FOG family of regulators of transcription factors. The family consists of the ZFPM1 and ZFPM2 genes in humans and Zfpm1 and Zfpm2 genes in mice. Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors. That is, the ZFPM2 protein appears able to interact directly with and thereby either enhance or repress the ability of GATA transcription factors to stimulate the expression of their target genes; the direction of ZFPM2's actions depends on the contexts of the promoter sections of the various GATA target genes.^[7]

The ZFPM2 protein interacts primarily with the GATA4 but also with GATA2, GATA5, and GATA6 transcription factors. ZFPM2 protein's interaction with GATA4 is notable for controlling the embryonic development of various tissues, particularly the heart, diaphragm, and gonads. Correspondingly, ZFPM2 mutations are responsible for certain forms of congenital heart defects, congenital diaphragmatic hernias,^[8] and ambiguous genitalia^[9] in mice as well as humans.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169946 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Svensson EC, Tufts RL, Polk CE, Leiden JM (March 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc Natl Acad Sci U S A. 96 (3): 956–61. Bibcode:1999PNAS...96..956S. doi:10.1073/pnas.96.3.956. PMC 15332. PMID 9927675.
^ Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B (September 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J Biol Chem. 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. PMID 10438528.
^ ^a ^b "Entrez Gene: ZFPM2 zinc finger protein, multitype 2".
^ Brady PD, Van Houdt J, Callewaert B, Deprest J, Devriendt K, Vermeesch JR (2014). "Exome sequencing identifies ZFPM2 as a cause of familial isolated congenital diaphragmatic hernia and possibly cardiovascular malformations". European Journal of Medical Genetics. 57 (6): 247–52. doi:10.1016/j.ejmg.2014.04.006. PMID 24769157.
^ Brauner R, Picard-Dieval F, Lottmann H, Rouget S, Bignon-Topalovic J, Bashamboo A, McElreavey K (November 2016). "Familial forms of disorders of sex development may be common if infertility is considered a comorbidity". BMC Pediatrics. 16 (1): 195. doi:10.1186/s12887-016-0737-0. PMC 5129225. PMID 27899089.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169946 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022306 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9927675-5] Svensson EC, Tufts RL, Polk CE, Leiden JM (March 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes". Proc Natl Acad Sci U S A. 96 (3): 956–61. Bibcode:1999PNAS...96..956S. doi:10.1073/pnas.96.3.956. PMC 15332. PMID 9927675.

[pmid10438528-6] Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B (September 1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J Biol Chem. 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. PMID 10438528.

[entrez-7] "Entrez Gene: ZFPM2 zinc finger protein, multitype 2".

[pmid24769157-8] Brady PD, Van Houdt J, Callewaert B, Deprest J, Devriendt K, Vermeesch JR (2014). "Exome sequencing identifies ZFPM2 as a cause of familial isolated congenital diaphragmatic hernia and possibly cardiovascular malformations". European Journal of Medical Genetics. 57 (6): 247–52. doi:10.1016/j.ejmg.2014.04.006. PMID 24769157.

[pmid27899089-9] Brauner R, Picard-Dieval F, Lottmann H, Rouget S, Bignon-Topalovic J, Bashamboo A, McElreavey K (November 2016). "Familial forms of disorders of sex development may be common if infertility is considered a comorbidity". BMC Pediatrics. 16 (1): 195. doi:10.1186/s12887-016-0737-0. PMC 5129225. PMID 27899089.

ZFPM2 information

and 9 Related for: ZFPM2 information

ZFPM2

List of human transcription factors

Tetralogy of Fallot

List of distinct cell types in the adult human body

GATA3

Induced stem cells

Merlin Crossley

List of OMIM disorder codes

CTBP2