Fospropofol information

Fospropofol
Clinical data
AHFS/Drugs.com	Monograph
License data	US FDA: Fospropofol;
Pregnancy; category	B;
Dependence; liability	unknown
Routes of; administration	Intravenous
ATC code	N01 ;
Legal status
Legal status	US: Schedule IV;
Pharmacokinetic data
Protein binding	98%
Metabolism	Hepatic glucuronidation
Elimination half-life	0.81 hours
Excretion	Renal
Identifiers
	IUPAC name disodium [2,6-di(propan-2-yl)phenoxy]methyl phosphate;
CAS Number	258516-89-1 ; 258516-87-9 (disodium salt);
PubChem CID	3038498;
DrugBank	DB06716 ;
ChemSpider	2302062 ;
UNII	LZ257RZP7K;
KEGG	D04257 ;
ChEMBL	ChEMBL1201766 ;
CompTox Dashboard (EPA)	DTXSID50870295 ;
Chemical and physical data
Formula	C13H21O5P
Molar mass	288.280 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)c1cccc(c1OCOP(=O)(O)O)C(C)C;
	InChI InChI=1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16) ; Key:QVNNONOFASOXQV-UHFFFAOYSA-N ;
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Fospropofol (INN^[3]), often used as the disodium salt (trade name Lusedra^[4]) is an intravenous sedative-hypnotic agent. It is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy.

^ ^a ^b "LUSEDRA (fospropofol disodium) Injection" (PDF). Woodcliff Lake, New Jersey: Eisai Inc. October 2009. Archived from the original (PDF) on 22 November 2010. Retrieved 2 August 2010.
^ "Fospropofol disodium". PubChem Compound. Bethesda, Maryland: U.S. National Library of Medicine. Retrieved 9 February 2017.
^ "Recommended INNs 2006, pt 56" (PDF). World Health Organization. Retrieved 20 April 2016.
^ "FDA Approves Fospropofol and Follows ASAs Labeling Recommendation". American Society of Anesthesiologists. 2008-12-15. Archived from the original on 2011-05-26. Retrieved 2011-03-30.

[Eisai2009-1] "LUSEDRA (fospropofol disodium) Injection" (PDF). Woodcliff Lake, New Jersey: Eisai Inc. October 2009. Archived from the original (PDF) on 22 November 2010. Retrieved 2 August 2010.

[PubChem-2] "Fospropofol disodium". PubChem Compound. Bethesda, Maryland: U.S. National Library of Medicine. Retrieved 9 February 2017.

[3] "Recommended INNs 2006, pt 56" (PDF). World Health Organization. Retrieved 20 April 2016.

[4] "FDA Approves Fospropofol and Follows ASAs Labeling Recommendation". American Society of Anesthesiologists. 2008-12-15. Archived from the original on 2011-05-26. Retrieved 2011-03-30.

Fospropofol information

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