Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Chloral hydrate is a geminal diol with the formula Cl3C−CH(OH)2. It was first used as a sedative and hypnotic in Germany in the 1870s. Over time it was replaced by safer and more effective alternatives but it remained in usage in the United States until at least the 1970s.[4] It sometimes finds usage as a laboratory chemical reagent and precursor. It is derived from chloral (trichloroacetaldehyde) by the addition of one equivalent of water.
^Vardanyan, R.S.; Hruby, V.J. (2006). "Soporific Agents (Hypnotics and Sedative Drugs)". Synthesis of Essential Drugs. pp. 57–68. doi:10.1016/B978-044452166-8/50004-2. ISBN 978-0-444-52166-8.
^Gawron, O.; Draus, F. (1958). "Kinetic Evidence for Reaction of Chloralate Ion with p-Nitrophenyl Acetate in Aqueous Solution". Journal of the American Chemical Society. 80 (20): 5392–5394. doi:10.1021/ja01553a018.
^Lide, D. R., ed. (2005). CRC Handbook of Chemistry and Physics (85th ed.). CRC Press. pp. 3–98. ISBN 978-0-8493-0484-2.
^Kales, Anthony (1 September 1970). "Hypnotic Drugs and Their Effectiveness: All-night EEG Studies of Insomniac Subjects". Archives of General Psychiatry. 23 (3): 226–232. doi:10.1001/archpsyc.1970.01750030034006. PMID 4318151.
Chloralhydrate is a geminal diol with the formula Cl3C−CH(OH)2. It was first used as a sedative and hypnotic in Germany in the 1870s. Over time it was...
Acetylglycinamide chloralhydrate is a hypnotic/sedative. It is a combination of acetylglycinamide and chloralhydrate. Degerholm E, Harison A, Leideman...
sulfuric acid. Another example is chloralhydrate, CCl3−CH(OH)2, which can be formed by reaction of water with chloral, CCl3−CH=O. Many organic molecules...
solvents. It reacts with water to form chloralhydrate, a once widely used sedative and hypnotic substance. Chloral was first prepared, and named, by the...
She had taken some barbiturates, but not a fatal dose. Traces of chloralhydrate were found, a drug normally associated with a "Mickey Finn" when combined...
decahydroxycyclopentane (C(OH) 2) 5 chloralhydrate (Cl 3C)HC(OH) 2. Geminal diols can be viewed as ketone (or aldehyde) hydrates. The two hydroxyl groups in...
Dichloralphenazone is a 1:2 mixture of antipyrine with chloralhydrate. In combination with paracetamol and isometheptene, it is the active ingredient...
died of "combined drug intoxication" with the sleeping medication chloralhydrate as the "major component". No illegal drugs were found in her system...
conjunction with other anesthetics, such as ketamine, barbiturates, chloralhydrate, and halothane in order to provide reliable anesthesia effects. The...
century. Treatment for insomnia in psychiatry dates back to 1869, when chloralhydrate was first used as a soporific. Barbiturates emerged as the first class...
combining water and propene in a hydration reaction or by hydrogenating acetone. There are two routes for the hydration process and both processes require...
on October 19, 1900. She was an early victim of the date rape drug chloralhydrate which caused her death. Her death received national news coverage and...
betaine complex of trimethylglycine with chloralhydrate, which acts as an extended-acting formulation of chloralhydrate which is then metabolized into trichloroethanol...
isomerises to trichloroacetaldehyde (chloral). Chloralhydrates to chloralhydrate in the body. Chloralhydrate is either reduced to 2,2,2-trichloroethanol...
requested a doctor for Williams, who was feeling the combination of the chloralhydrate and alcohol he consumed on the way from Montgomery. A doctor injected...
amphetamine, mescaline, lysergic acid diethylamide (LSD), cannabis, chloralhydrate, theophylline, IBMX and others, can have strong effects on certain...
sedative, hypnotic and weak local anesthetic similar in nature to chloralhydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically...
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