Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered intravenously to deliver phenytoin, potentially more safely than intravenous phenytoin. It is used in the acute treatment of convulsive status epilepticus.
Fosphenytoin was developed in 1996.[2] On 18 November 2004, Sicor (a subsidiary of Teva) received a tentative approval letter from the United States Food and Drug Administration for a generic version of fosphenytoin.[3]
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^Pitkänen A, Schwartzkroin PA, Moshé SL (2005). Models of Seizures and Epilepsy. Burlington: Elsevier. p. 539. ISBN 9780080457024.
^"Fosphenytoin Sodium Approval History". Retrieved 20 October 2005.
Fosphenytoin, also known as fosphenytoin sodium, and sold under the brand name Cerebyx among others, is a water-soluble phenytoin prodrug that is administered...
antiseizure drugs should be given, including valproic acid (valproate), fosphenytoin, levetiracetam, or a similar substance(s). While empirically based treatments...
over-the-counter decongestant Phenytoin equivalent, used to measure doses of fosphenytoin Physical exercise Prolonged exposure therapy, a form of behavior therapy...
antiepileptic drugs: Gabapentin, lamotrigine, felbamate, topiramate and fosphenytoin". American Family Physician. 57 (3): 513–20. PMID 9475899. v t e v t...
following are hydantoins: Ethotoin (1957). Phenytoin (1938). Mephenytoin. Fosphenytoin (1996). The following are oxazolidinediones: Paramethadione. Trimethadione...
Antiepileptic Drugs: Gabapentin, Lamotrigine, Felbamate, Topiramate and Fosphenytoin". Am Fam Physician. 57 (3): 513–20. PMID 9475899. Archived from the original...
hydantoin derivatives form a class of anticonvulsants; phenytoin and fosphenytoin both contain hydantoin moieties and are both used as anticonvulsants...
oxycodone due to strong induction of CYP3A4. There is also a case report of fosphenytoin, a CYP3A4 inducer, dramatically reducing the analgesic effects of oxycodone...
propofol may be used. Second-line therapy for adults is phenytoin or fosphenytoin and phenobarbital for children.[page needed] Third-line medications include...
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