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Minoxidil information


Minoxidil
A space filling model of the molecule.
Clinical data
Trade namesLoniten, Rogaine, others
Other names2,4-Diamino-6-piperidinopyrimidine 3-oxide
AHFS/Drugs.comMonograph
MedlinePlusa682608
License data
  • US DailyMed: Minoxidil
Pregnancy
category
  • AU: C[1]
Routes of
administration
By mouth, topical
ATC code
  • C02DC01 (WHO) D11AX01 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only) / S2[1][3][4]
  • UK: General sales list (GSL, OTC) / POM[5][6][7]
  • US: WARNING[2]OTC / Rx-only[8][9]
Pharmacokinetic data
MetabolismPrimarily liver
Elimination half-life4.2 h
ExcretionKidney
Identifiers
IUPAC name
  • 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
CAS Number
  • 38304-91-5 checkY
PubChem CID
  • 4201
IUPHAR/BPS
  • 4254
DrugBank
  • DB00350 ☒N
ChemSpider
  • 10438564 checkY
UNII
  • 5965120SH1
KEGG
  • D00418 ☒N
ChEBI
  • CHEBI:6942 ☒N
ChEMBL
  • ChEMBL802 ☒N
PDB ligand
  • MXD (PDBe, RCSB PDB)
CompTox Dashboard (EPA)
  • DTXSID9040685 Edit this at Wikidata
ECHA InfoCard100.048.959 Edit this at Wikidata
Chemical and physical data
FormulaC9H15N5O
Molar mass209.253 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point248 °C (478 °F)
Solubility in water<1
SMILES
  • Nc1cc(nc(N)[n+]1[O-])N2CCCCC2
InChI
  • InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6H,1-5,10H2,(H2,11,12) ☒N
  • Key:ZFMITUMMTDLWHR-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Minoxidil is a medication used for the treatment of high blood pressure and pattern hair loss.[5][6][7] It is an antihypertensive and a vasodilator.[10] It is available as a generic medication by prescription in oral tablet form and over the counter as a topical liquid or foam.[8][9][11][12]

  1. ^ a b "Loniten Product Information". Therapeutic Goods Administration (TGA). Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved October 22, 2023.
  3. ^ "59445 WOMEN'S REGAINE EXTRA STRENGTH Minoxidil 5% application bottle". Therapeutic Goods Administration (TGA) / Australian Government Department of Health and Aged Care. Retrieved February 15, 2022.
  4. ^ "Search the TGA website". Tga-search.clients.funnelback.com. Archived from the original on August 16, 2021.
  5. ^ a b "Loniten Tablets 5mg - Summary of Product Characteristics (SmPC)". Medicines.org.uk. November 24, 2020. Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  6. ^ a b "Regaine for Men Extra Strength Scalp Foam 5% w/w Cutaneous Foam (GSL) - Summary of Product Characteristics (SmPC)". (emc). April 27, 2021. Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  7. ^ a b "Regaine for Women Once a Day Scalp Foam 5% w/w Cutaneous Foam - Summary of Product Characteristics (SmPC)". Medicines.org.uk. October 28, 2020. Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  8. ^ a b "Minoxidil tablet". DailyMed. Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  9. ^ a b "Minoxidil aerosol, foam". DailyMed. Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  10. ^ "Vasodilators". mayoclinic.com. Archived from the original on March 9, 2011.
  11. ^ "Mens Rogaine Extra Strength Unscented- minoxidil solution". DailyMed. Archived from the original on August 16, 2021. Retrieved August 15, 2021.
  12. ^ "Womens Rogaine Unscented- minoxidil solution". DailyMed. Archived from the original on August 16, 2021. Retrieved August 15, 2021.

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Minoxidil

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Minoxidil is a medication used for the treatment of high blood pressure and pattern hair loss. It is an antihypertensive and a vasodilator. It is available...

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Minoxidil sulfate

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Minoxidil sulfate, also known as minoxidil sulfate ester or minoxidil N-O-sulfate, is an active metabolite of minoxidil (Rogaine, Loniten, others) and...

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Kopexil

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diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was...

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Hair loss

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glycol in the minoxidil solution and a minoxidil foam was developed without propylene glycol. Not all users will regrow hair. Minoxidil may also be taken...

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Collagen induction therapy

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shown that when combined with minoxidil treatment, microneedling is able to treat hair loss more effectively than minoxidil treatment alone. Platelet-rich...

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Hypertrichosis

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condition known as trichiasis. Oral minoxidil treatments for hypertension are known to cause this condition. Topical minoxidil used for alopecia causes hair...

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Telogen effluvium

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which causes a massive release of club (telogen) hairs. Drugs such as minoxidil can precipitate immediate telogen release. Delayed telogen release involves...

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Management of hair loss

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finasteride, minoxidil and ketoconazole are more effective than individual use. Combination therapy of LLLT or microneedling with finasteride or minoxidil demonstrated...

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Ear hair

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localized otitis externa. Severe hypertrichosis of the external ear during minoxidil therapy, where excessive hair covers the ears, may cause ear canal occlusion...

Word Count : 535

Alopecia areata

Last Update:

known. Some treatments, particularly triamcinolone injections and 5% minoxidil topical creams, are effective in speeding hair regrowth. Sunscreen, head...

Word Count : 4218

SULT1A1

Last Update:

(androgenetic alopecia patients) is a pro-drug. Minoxidil is converted to its active form (minoxidil sulfate) by the hair sulfotransferase enzyme (SULT1A1)...

Word Count : 1142

Adenosine

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study compared topical adenosine with minoxidil in male androgenetic alopecia, finding it was as potent as minoxidil (in overall treatment outcomes) but...

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Pattern hair loss

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aspect of the condition. Otherwise, common medical treatments include minoxidil, finasteride, dutasteride, or hair transplant surgery. Use of finasteride...

Word Count : 9789

Tretinoin

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as a way to increase the ability of minoxidil (by acting as an enzyme and accelerating the production of minoxidil sulfate) to penetrate the scalp, but...

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Hirsutism

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recommendation is to stop the medication and replace it with another. Minoxidil Androgens like testosterone, anabolic steroids, and androgenic progestins...

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Acromegaly

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frequently associated with insulin resistance. Cases have been reported due to minoxidil at an unusually high dose. It can also be caused by a selective post receptor...

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Simpson and Delilah

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Nuclear Power Plant's medical insurance plan to buy Dimoxinil (a parody of Minoxidil), a miracle hair growth formula. When Homer's bald head sprouts a full...

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Rogaine

Last Update:

Rogaine may refer to: Rogaine, one brand of minoxidil, a hair-regrowth medication Rogaining, a team sport of cross-country navigation This disambiguation...

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Vasodilation

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cocoa solids (which is found in chocolate, especially dark chocolate) minoxidil papaverine an alkaloid found in the opium poppy papaver somniferum estrogen...

Word Count : 4136

Cocaine

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Bimakalim Cromakalim Diazoxide Emakalim Levcromakalim Mazokalim Minoxidil Minoxidil sulfate Naminidil Nicorandil Pinacidil Rilmakalim Sarakalim GIRKTooltip...

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Non scarring hair loss

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infections. Depending on the cause, treatment options include: topical minoxidil, oral finasteride, anti-fungal medications, steroids, hair transplantation...

Word Count : 1792

Rubefacient

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irritation without rubefaction" Isopropanol (rubbing alcohol) Menthol Minoxidil Thurfyl nicotinate (Trafuril) Common herbal rubefacients include:[citation...

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Drug of last resort

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where conventional therapy is not sufficient. Oral minoxidil for hypertension, however topical minoxidil is a first-line drug for hair loss. Monoamine oxidase...

Word Count : 1781

Scalp

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be treated with varying rates success by medication (e.g. finasteride, minoxidil) or hair transplantation. If the scalp is heavy and loose, a common change...

Word Count : 1325

Cat health

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administration of minoxidil in 2 cats". Journal of Veterinary Emergency and Critical Care. 14 (4): 287–292. doi:10.1111/j.1476-4431.2004.04014.x. "Minoxidil Warning"...

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Gabapentin

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Bimakalim Cromakalim Diazoxide Emakalim Levcromakalim Mazokalim Minoxidil Minoxidil sulfate Naminidil Nicorandil Pinacidil Rilmakalim Sarakalim GIRKTooltip...

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Arteriolar vasodilator

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leading to vasodilatory edema. Arteriolar vasodilators include: hydralazine minoxidil nitroprusside Messerli, F (September 2001). "Vasodilatory edema: a common...

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Trichology

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inhibitor’s Dutasteride, Finasteride Antifungal Ketoconazole Antihypertensive Minoxidil International Association of Trichologists (IAT) American Hair Research...

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Piperidine

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SERM (selective estrogen receptor modulators) Raloxifene Vasodilators Minoxidil Antipsychotic medications: Droperidol Haloperidol Melperone Mesoridazine...

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