The homodimer structure of Emopamil binding protein is shown.
Emopamil binding protein is a protein that in humans is encoded by the EBPgene, located on the X chromosome.[5] The protein is shown to have a high-affinity reception for anti-ischemic drugs, such as Emopamil, resulting in its discovery and given name. EBP has a mass of 27.3 kDa and resembles a σ-receptor that resides in the endoplasmic reticulum of various tissues as an integral membrane protein.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000147155 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031168 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Guggenberger C, Ilgen D, Adamski J (May 2007). "Functional analysis of cholesterol biosynthesis by RNA interference". The Journal of Steroid Biochemistry and Molecular Biology. 104 (3–5): 105–109. doi:10.1016/j.jsbmb.2007.03.001. PMID 17498944. S2CID 20838858.
^Hanner M, Moebius FF, Weber F, Grabner M, Striessnig J, Glossmann H (March 1995). "Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression". The Journal of Biological Chemistry. 270 (13): 7551–7557. doi:10.1074/jbc.270.13.7551. PMID 7706302.
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Emopamilbindingprotein is a protein that in humans is encoded by the EBP gene, located on the X chromosome. The protein is shown to have a high-affinity...
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Wang D (June 2002). "Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated...
cholinergic receptors, as its binding affinity for them is nearly non-existent. It can also bind to vertebral emopamilbindingprotein (EBP). Although EBP exists...
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advice database (TCAs are protein bound and become less bound in more acidic conditions, so by reversing the acidosis, proteinbinding increases and bioavailability...
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Minoxidil acts as an activator of the Kir6/SUR2 channel upon selective binding to SUR2. The expression of SUR2B in dermal papilla cells might play a role...
employing the tactic. In 1988, the synthesis and binding studies of an artificial receptor binding barbiturates by six complementary hydrogen bonds was...
control seizures. Dialysis is of no use due to the high degree of proteinbinding with amitriptyline. Since amitriptyline and its active metabolite nortriptyline...
is rapidly distributed into the brain and other tissues. The plasma proteinbinding of ketamine is variable at 23–47%. In the body ketamine undergoes extensive...
pharmacokinetic properties (poor water and lipid solubility, high proteinbinding and anoxidative metabolism to a pharmacologically inactive glucuronide...
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily...
"Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I". Proceedings of the National...
ligand-gated ion channel Ion channels mediated by the binding of small molecules to the channel protein mechanosensitive ion channels Ion channels that respond...
internal signaling events through protein kinase A, which ultimately phosphorylate cAMP response element bindingprotein (CREB), inducing CREB-mediated changes...
main action is exhibited specifically by its binding to the α2δ subunit of VDCCs, so that this binding modulates calcium influx at the nerve terminals...
intracellular mechanism such as antagonising calmodulin, a calcium bindingprotein. Flunarizine is well absorbed (>80%) from the gut and reaches maximal...
intrinsic sympathomimetic activity. Without the binding of catecholamines to the β-adrenergic receptor, the G protein complex associated with the receptor cannot...
ineffective because most of the lercanidipine is bound to blood plasma proteins and lipid membranes of cells. The substance is metabolised by the liver...
methysticin) and possibly also of dopamine (by kavain and desmethoxyyangonin). Binding to the CB1 receptor (by yangonin). Inhibition of voltage-gated sodium channels...
Despite structural differences, promethazine exhibits a strikingly similar binding profile to promazine, another phenothiazine compound. Both promethazine...
Suzuki Y, Tagawa T, Karasawa T, Yabuuchi H (March 1990). "[3H]zonisamide binding in rat brain". Medical Journal of Osaka University. 39 (1–4): 19–22. PMID 1369647...
food; the maximum concentration decreases by 20%. Distribution: The proteinbinding of repalglinide to albumin is greater than 98%. Metabolism: repaglinide...
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