Molecule able to block protein channels, frequently used as pharmaceutical
Tetrodotoxin, an example of a channel block molecule.
A channel blocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological response in a cell. Channel blocking is conducted by different types of molecules, such as cations, anions, amino acids, and other chemicals. These blockers act as ion channel antagonists, preventing the response that is normally provided by the opening of the channel.
Ion channels permit the selective passage of ions through cell membranes by utilizing proteins that function as pores, which allow for the passage of electrical charge in and out of the cell.[1] These ion channels are most often gated, meaning they require a specific stimulus to cause the channel to open and close. These ion channel types regulate the flow of charged ions across the membrane and therefore mediate membrane potential of the cell.
Molecules that act as channel blockers are important in the field of pharmacology, as a large portion of drug design is the use of ion channel antagonists in regulating physiological response. The specificity of channel block molecules on certain channels makes it a valuable tool in the treatment of numerous disorders.[2][3]
^"Medical Definition of Ion channel". MedicineNet. Retrieved 2017-03-20.
^Cite error: The named reference Kocahan_2017 was invoked but never defined (see the help page).
^Cite error: The named reference Lipton_2004 was invoked but never defined (see the help page).
occur in as much as 70% of people receiving calcium channelblocker, is caused by calcium channelblockers' preferential arteriolar or precapillary dilation...
A channelblocker is the biological mechanism in which a particular molecule is used to prevent the opening of ion channels in order to produce a physiological...
such as gliclazide, are ATP-sensitive potassium channelblockers. Dalfampridine, A potassium channelblocker has also been approved for use in the treatment...
β-blocker-induced bronchospasm where it exerts greater efficacy on reversing selective β-blocker-induced bronchospasm than the nonselective β-blocker-induced...
calcium channelblocker but as an antimineralocorticoid. Calcium channelblocker (including section on non-dihydropyridine calcium channelblockers) Calcium...
Calcium channelblocker toxicity is the taking of too much of the medications known as calcium channelblockers (CCBs), either by accident or on purpose...
inhibitor) or amlodipine (a calcium channelblocker). (ALLHAT showed that doxazosin, an alpha-adrenergic receptor blocker, had a higher incidence of heart...
chloride channel blocker that has been used in experimental scientific research. Another example is anthracene-9-carboxylic acid, a potent blocker of the CLCN1-type...
most countries. Remacemide: a low affinity antagonist also a sodium-channelblocker. Rolicyclidine: a less potent analogue of phencyclidine, but seems...
qualification, it can refer to an α1 blocker, an α2 blocker, a nonselective blocker (both α1 and α2 activity), or an α blocker with some β activity. However...
An epithelial sodium channelblocker is a sodium channelblocker that is selective for the epithelial sodium channel. An example is amiloride, which is...
Amlodipine, sold under the brand name Norvasc among others, is a calcium channelblocker medication used to treat high blood pressure, coronary artery disease...
V1848I, but is not yet reported for another voltage-dependent sodium channelblocker, metafumizone (22B). (These two mutations, as with the diamides above...
pharmacological modulators of potassium channels, see potassium channelblocker and potassium channel opener. Potassium channels have a tetrameric structure in...
brand name Cardizem among others, is a nondihydropyridine calcium channelblocker medication used to treat high blood pressure, angina, and certain heart...
agents predominantly block the potassium channels, thereby prolonging repolarization. Since these agents do not affect the sodium channel, conduction velocity...
with calcium channelblocker may increase risk of low blood pressure, kidney failure, and death, compared to pairing calcium channelblockers with azithromycin...
a brand of programming blocks and international cable and satellite television channels that were owned by the Disney Channels Worldwide unit (now Disney...
Potassium channel opener Sodium channel: see also Sodium channelblocker, Sodium channel opener Chloride channel: see also Chloride channelblocker, Chloride...
Nifedipine, sold under the brand name Procardia among others, is a calcium channelblocker medication used to manage angina, high blood pressure, Raynaud's phenomenon...
Verapamil, sold under various trade names, is a calcium channelblocker medication used for the treatment of high blood pressure, angina (chest pain from...
adenosine may be tried. If adenosine is not effective a calcium channelblocker or beta blocker may be used. Otherwise synchronized cardioversion is the treatment...
PMID 21896151. Stern, Simon (2018-05-24). "The Effects of Calcium ChannelBlocker Drugs on Gingival Vasculature". dx.doi.org. doi:10.26226/morressier...
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