Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms.[1] Evidence does not support a decreased risk of death with long term use.[1] It is taken by mouth or given by injection into a vein.[1]
Common side effects include a slow heart rate, chest pain, low blood pressure, feeling tired, dizziness, shortness of breath, problems seeing, vomiting, and swelling.[1] Other serious side effects may include QT prolongation, heart failure, or bronchospasm.[4] Sotalol is a non-selective β-adrenergic receptor blocker which has both class II and class III antiarrhythmic properties.[1]
Sotalol was first described in 1964 and came into medical use in 1974.[5] It is available as a generic medication.[4] In 2020, it was the 296th most commonly prescribed medication in the United States, with more than 1million prescriptions.[6][7]
^ abcdef"Sotalol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 March 2019.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ abcdCite error: The named reference fda2009 was invoked but never defined (see the help page).
^ abBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 108. ISBN 9780857113382.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 460. ISBN 9783527607495.
^"The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
^"Sotalol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
Sotalol, sold under the brand name Betapace among others, is a medication used to treat and prevent abnormal heart rhythms. Evidence does not support...
certain beta-blockers: Long QT syndrome: sotalol is contraindicated History of torsades de pointes: sotalol is contraindicated Cautions: Abrupt discontinuations...
result of myocardial ischemia. Class III anti-arrhythmic drugs such as sotalol and amiodarone prolong the QT interval and may in some circumstances be...
polymorphic VT). Class III agents include: bretylium, amiodarone, ibutilide, sotalol, dofetilide, vernakalant, and dronedarone. Class IV agents are slow non-dihydropyridine...
Propranolol Type III (potassium channel blockers) Amiodarone Dofetilide Sotalol Type IV (slow calcium channel blockers) Diltiazem Verapamil Type V Adenosine...
genetic conditions such as long QT syndrome, by certain medications such as sotalol or pitolisant, by disturbances in the concentrations of certain salts within...
cardiac (antiarrhythmic) drugs, as a sulfonamide moiety. Examples include sotalol, ibutilide, sematilide, dronedarone, dofetilide, E-4031, and bitopertin...
amiodarone-treated group as opposed to 6.6% of the control group (taking placebo or sotalol). Overt hypothyroidism (defined as TSH >10 mU/L) occurred at 5.0% compared...
the most popular antiarrhythmic drug in the study was sotalol with 52,750 users, and sotalol had a TdP incidence of 81.1 cases and 41.2 cases of TdP...
purpose, including atenolol, procainamide, sotalol, mexiletine, and amiodarone. Combinations can also be used. Sotalol is probably the most commonly used antiarrhythmic...
effect with alpha-blockers; increased risk of ventricular arrhythmias with sotalol if hypokalemia occurs Antipsychotics: increased risk of ventricular arrhythmias...
effects than beta blockers with more hydrophilic molecules such as atenolol, sotalol and nadolol. Oxprenolol is a potent beta blocker and should not be administered...
right ventricular cardiomyopathy (ARVC) in Boxer dogs in combination with sotalol.[medical citation needed] "Product monograph brand safety updates". Health...
shown as a side effect of certain anti-arrhythmic medications, such as sotalol, procainamide, quinidine, ibutilide, and dofetilide. In one example, the...
involve the AV node may respond to other anti-arrhythmic drugs such as sotalol or amiodarone.[citation needed] If the person is hemodynamically unstable...
(prolong repolarization by blocking outward K+ current): amiodarone and sotalol are effective class III agents. Ibutilide is another Class III agent but...
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