Edivoxetine information

Edivoxetine
Clinical data
ATC code	None;
Legal status
Legal status	Development terminated;
Identifiers
	IUPAC name (1R)-2-(5-fluoro-2-methoxyphenyl)-1-[(2S)-morpholin-2-yl]-1-(tetrahydro-2H-pyran-4-yl)ethanol;
CAS Number	1194508-25-2 ; 1194374-05-4 (hydrochloride);
PubChem CID	11186829;
ChemSpider	9361913;
UNII	3W9N3F4JOO;
KEGG	D09890;
CompTox Dashboard (EPA)	DTXSID70152464 ;
Chemical and physical data
Formula	C18H26FNO4
Molar mass	339.407 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=C(C=C(C=C1)F)C[C@]([C@@H]2CNCCO2)(C3CCOCC3)O;
	InChI InChI=1S/C18H26FNO4/c1-22-16-3-2-15(19)10-13(16)11-18(21,14-4-7-23-8-5-14)17-12-20-6-9-24-17/h2-3,10,14,17,20-21H,4-9,11-12H2,1H3/t17-,18+/m0/s1; Key:CPBHSHYQQLFAPW-ZWKOTPCHSA-N;

Edivoxetine (INN; code name LY-2216684) is a drug which acts as a selective norepinephrine reuptake inhibitor and was under development by Eli Lilly for attention-deficit disorder (ADD) and as an antidepressant treatment.^[1]^[2] It was in phase III clinical trials in 2012 for major depressive disorder, but failed to get approval.^[1]^[3]

^ ^a ^b Jun Yan (March 2012). "Pipeline for new antidepressants flowing slowly". Psychiatric News. 47 (5): 1b–29. doi:10.1176/pn.47.5.psychnews_47_5_1-b. Retrieved 2012-04-27. {{cite journal}}: Unknown parameter |agency= ignored (help)
^ "Statement on a nonproprietary name adopted by the USAN council - Edivoxetine" (PDF) (Press release). American Medical Association. 2012. Retrieved 2012-04-12.
^ Chancellor D (November 2011). "The depression market". Nature Reviews. Drug Discovery. 10 (11): 809–10. doi:10.1038/nrd3585. PMID 22037032. S2CID 3194093.

[Yan2012-1] Jun Yan (March 2012). "Pipeline for new antidepressants flowing slowly". Psychiatric News. 47 (5): 1b–29. doi:10.1176/pn.47.5.psychnews_47_5_1-b. Retrieved 2012-04-27. {{cite journal}}: Unknown parameter |agency= ignored (help)

[AMA2012-2] "Statement on a nonproprietary name adopted by the USAN council - Edivoxetine" (PDF) (Press release). American Medical Association. 2012. Retrieved 2012-04-12.

[pmid22037032-3] Chancellor D (November 2011). "The depression market". Nature Reviews. Drug Discovery. 10 (11): 809–10. doi:10.1038/nrd3585. PMID 22037032. S2CID 3194093.

Edivoxetine information

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Clinical data


ATC code	None
Legal status
Legal status	Development terminated
Identifiers
IUPAC name (1R)-2-(5-fluoro-2-methoxyphenyl)-1-[(2S)-morpholin-2-yl]-1-(tetrahydro-2H-pyran-4-yl)ethanol
CAS Number	1194508-25-2 1194374-05-4 (hydrochloride)
PubChem CID	11186829
ChemSpider	9361913
UNII	3W9N3F4JOO
KEGG	D09890
CompTox Dashboard (EPA)	DTXSID70152464
Chemical and physical data
Formula	C₁₈H₂₆FNO₄
Molar mass	339.407 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=C(C=C(C=C1)F)C[C@]([C@@H]2CNCCO2)(C3CCOCC3)O
InChI InChI=1S/C18H26FNO4/c1-22-16-3-2-15(19)10-13(16)11-18(21,14-4-7-23-8-5-14)17-12-20-6-9-24-17/h2-3,10,14,17,20-21H,4-9,11-12H2,1H3/t17-,18+/m0/s1 Key:CPBHSHYQQLFAPW-ZWKOTPCHSA-N