Duloxetine, sold under the brand name Cymbalta among others,[1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, fibromyalgia, neuropathic pain and central sensitization.[7][8] It is taken by mouth.[7]
Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI).[9] Similarly to SSRIs and other SNRIs, the precise mechanism for its antidepressant and anxiolytic effects is not known.[7]
Common side effects include dry mouth, nausea, feeling tired, dizziness, agitation, sexual problems, and increased sweating.[7] Severe side effects include an increased risk of suicide, serotonin syndrome, mania, and liver problems.[7] Antidepressant withdrawal syndrome may occur if stopped.[7] There are concerns that use during the later part of pregnancy can harm the developing fetus.[7]
Duloxetine was approved for medical use in the United States and in the European Union in 2004.[5][6][7] It is available as a generic medication.[9] In 2021, it was the 27th most commonly prescribed medication in the United States, with more than 20million prescriptions.[10][11]
^ ab"Duloxetine". Drugs.com. Archived from the original on 29 September 2018. Retrieved 24 December 2018.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). 31 March 2023. Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^Cite error: The named reference Cymbalta FDA label was invoked but never defined (see the help page).
^ ab"Cymbalta EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 20 October 2020. Retrieved 30 September 2020.
^ abCite error: The named reference EMA-2018-EPAR was invoked but never defined (see the help page).
^ abcdefgh"Duloxetine". Monograph. The American Society of Health-System Pharmacists. Archived from the original on 26 November 2018. Retrieved 24 December 2018.
^"Medications for OCD". International OCD Foundation. Archived from the original on 27 January 2024. Retrieved 25 February 2024.
^ abBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 364–365. ISBN 9780857113382.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Duloxetine - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 14 January 2024.
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive-compulsive...
that online anecdotal reports of discontinuation syndrome related to duloxetine included severe symptoms and exceeded prevalence of both paroxetine and...
although antidepressants can improve quality of life. The medications duloxetine, milnacipran, or pregabalin have been approved by the US Food and Drug...
anxiety as his parents offer him Duloxetine in Tape 1, Side B, which he has taken before for an unknown reason. Duloxetine is an antidepressant used to treat...
Lenox-Smith A, Bradley A (June 2013). "A review of the suitability of duloxetine and venlafaxine for use in patients with depression in primary care with...
medical conditions including neuropathic pain and fibromyalgia (e.g., duloxetine, milnacipran), and premature ejaculation (e.g., dapoxetine) as well as...
of previous studies showed that the agents carbamazepine, venlafaxine, duloxetine, and amitriptyline were more effective than placebo, but that comparative...
anti-convulsant drug such as pregabalin. There is some evidence that duloxetine can also be used in some cases of neuropathic pain, especially in patients...
sexual dysfunction with vortioxetine was similar to that with the SNRI duloxetine, which had an incidence of 26 to 28% at the used dosage of 60 mg/day....
serotonin syndrome when cyclobenzaprine was taken with the serotonergic drugs duloxetine or phenelzine. These substances may interact with cyclobenzaprine: Central...
Currently (as of 2017) the three most sold antidepressants in Japan are duloxetine, mirtazapine, and escitalopram (Lexapro). The three most sold antidepressants...
first-generation (such as amitriptyline) and newer antidepressants (such as duloxetine) are used alongside NSAIDs and opioids for pain involving nerve damage...
for its clinical depression drugs Prozac (fluoxetine) (1986), Cymbalta (duloxetine) (2004), and its antipsychotic medication Zyprexa (olanzapine) (1996)...
Manerix). Serotonin reuptake inhibitors such as citalopram (Celexa), duloxetine (Cymbalta), fluoxetine (Prozac), and paroxetine (Paxil) have been shown...
more research is needed to be certain. Sertraline, escitalopram, and duloxetine may also help reduce symptoms. A 2023 systematic review and meta-analysis...
effective at relieving pain as duloxetine and amitriptyline. Combination treatment of pregabalin and amitriptyline or duloxetine offers additional pain relief...
inhibitor (SNRIs) include venlafaxine and duloxetine drugs. Venlafaxine, in extended release form, and duloxetine, are indicated for the treatment of GAD...
Global Information
(what is this?) (verify)