Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias.[4] This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia.[4] Evidence in cardiac arrest, however, is poor.[5] It can be given by mouth, intravenously, or intraosseously.[4] When used by mouth, it can take a few weeks for effects to begin.[4][6]
Common side effects include feeling tired, tremor, nausea, and constipation.[4] As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias.[4] Serious side effects include lung toxicity[7] such as interstitial pneumonitis, liver problems, heart arrhythmias, vision problems, thyroid problems, and death.[4] If taken during pregnancy or breastfeeding it can cause problems in the fetus or the infant.[4] It is a class III antiarrhythmic medication.[4] It works partly by increasing the time before a heart cell can contract again.[4][6]
Amiodarone was first made in 1961 and came into medical use in 1962 for chest pain believed to be related to the heart.[8] It was pulled from the market in 1967 due to side effects.[9] In 1974 it was found to be useful for arrhythmias and reintroduced.[9] It is on the World Health Organization's List of Essential Medicines.[10] It is available as a generic medication.[4] In 2021, it was the 235th most commonly prescribed medication in the United States, with more than 1million prescriptions.[11][12][6]
^"Pacerone- amiodarone hydrochloride tablet". DailyMed. Archived from the original on 29 December 2022. Retrieved 8 September 2021.
^"Cordarone (amiodarone) tablets, for oral use Initial U.S. Approval: 1985". DailyMed. 30 October 2018. Archived from the original on 29 December 2022. Retrieved 8 September 2021.
^"Nexterone- Amiodarone HCl injection, solution". DailyMed. Archived from the original on 29 December 2022. Retrieved 8 September 2021.
^ abcdefghijk"Amiodarone Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 19 September 2016. Retrieved 22 August 2016.
^Ali MU, Fitzpatrick-Lewis D, Kenny M, Raina P, Atkins DL, Soar J, et al. (November 2018). "Effectiveness of antiarrhythmic drugs for shockable cardiac arrest: A systematic review" (PDF). Resuscitation. 132: 63–72. doi:10.1016/j.resuscitation.2018.08.025. PMID 30179691. S2CID 52154562. Archived (PDF) from the original on 5 March 2020. Retrieved 17 December 2019.
^ abcReview of the Medical Use of Amiodarone (Nexterone, Pacerone). Xavier Research Press. 24 July 2018. ISBN 978-1-7242-7798-5.
^Analytical Profiles of Drug Substances and Excipients. Academic Press. 1992. p. 4. ISBN 978-0-08-086115-9. Archived from the original on 8 September 2017.
^ abFischer J, Ganellin CR (2005). Analogue-based Drug Discovery. John Wiley & Sons. p. 12. ISBN 978-3-527-60749-5. Archived from the original on 8 September 2017.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Amiodarone - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia (VT)...
Amiodarone induced thyrotoxicosis (AIT) is a form of hyperthyroidism due to treatment with antiarrhythmic drug, amiodarone. Amiodarone induced thyroid...
development of polymorphic VT). Class III agents include: bretylium, amiodarone, ibutilide, sotalol, dofetilide, vernakalant, and dronedarone. Class IV...
being indicated in arrhythmias, it was recommended as an alternative to amiodarone for the treatment of atrial fibrillation and atrial flutter in people...
can be done, the use of the medicinal drug amiodarone: a) Prescribing the lowest possible dose of amiodarone leads to a lower incidence of pulmonary toxicity...
administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone. It is also used as an excipient in some European and Canadian influenza...
cardiac defibrillator or medications such as calcium channel blockers or amiodarone may be used to prevent recurrence. While a few seconds may not result...
golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Furthermore, it is a common adverse side effect of the use of...
calcium channel blockers, verapamil and diltiazem, as well as those taking amiodarone. Common side effects (>1% incidence) may include indigestion and eczema...
decreasing the dosage of amiodarone, the severity of the anosmia decreased accordingly, suggesting a relationship between use of amiodarone to the development...
shockable rhythm. Amiodarone and lidocaine are anti-arrhythmic medications. Amiodarone is a class III anti-arrhythmic. Amiodarone may be used in cases...
Some medications may cause discoloration such as medications containing amiodarone or silver. Furthermore, mongolian spots, large birthmarks, and the consumption...
antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials. Amiodarone is considered the most effective antiarrhythmic...
sunlight; these include most of the tetracycline antibiotics, heart drugs amiodarone, and sulfonamides. Some dietary supplements, such as St. John's Wort,...
powerful medication called amiodarone to treat an irregular heartbeat. Amiodarone can cause lung damage (known as "amiodarone pulmonary toxicity") and,...
of vasectomy. Chemical epididymitis may also result from drugs such as amiodarone. Diagnosis is typically based on symptoms. Conditions that may result...
refractory). Amiodarone is indicated for the treatment of refractory VT or VF, particularly in the setting of acute ischemia. Amiodarone is also safe...
people taking other medications that affect the QT interval (such as amiodarone). Vardenafil was co-marketed by Bayer Pharmaceuticals, GlaxoSmithKline...
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