Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about a medical abortion during pregnancy and manage early miscarriage.[5] This combination is 97% effective during the first 63 days of pregnancy.[6] It is also effective in the second trimester of pregnancy.[7][8] It is taken by mouth.[5]
The more common adverse effects include abdominal pain, feeling tired, and vaginal bleeding.[5] Serious side effects may include heavy vaginal bleeding, bacterial infection, and birth defects if the pregnancy does not end.[5] If used, appropriate follow-up care needs to be available.[5][9] Mifepristone is an antiprogestogen.[5] It works by blocking the effects of progesterone, making both the cervix and uterine vessels dilate and causing uterine contraction.[5]
Mifepristone was developed in 1980 and came into use in France in 1987.[10] It became available in the United States in 2000.[11][7] It is on the World Health Organization's List of Essential Medicines.[12][13] Mifepristone was approved in Canada in January 2017.[14][15]
^"mifepristone". Mifepristone Definition & Meaning - Merriam-Webster. Merriam-Webster.com Dictionary. Merriam-Webster. Archived from the original on 3 March 2023. Retrieved 3 March 2023.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^Cite error: The named reference Korlym FDA label was invoked but never defined (see the help page).
^"Mifepristone tablet". DailyMed. 30 March 2023. Archived from the original on 10 April 2023. Retrieved 24 April 2023.
^ abcdefg"Mifepristone". American Society of Health System Pharmacists. Archived from the original on 22 December 2015. Retrieved 25 February 2023 – via Drugs.com.
^Chen MJ, Creinin MD (July 2015). "Mifepristone With Buccal Misoprostol for Medical Abortion: A Systematic Review". Obstetrics and Gynecology. 126 (1): 12–21. doi:10.1097/AOG.0000000000000897. PMID 26241251. S2CID 20800109. Archived from the original on 26 July 2020. Retrieved 27 July 2019 – via eScholarship.
^ abGoldman MB, Troisi R, Rexrode KM, eds. (2012). Women and Health (2nd ed.). Oxford: Academic Press. p. 236. ISBN 978-0-12-384979-3. Archived from the original on 8 September 2017. Retrieved 5 September 2017 – via Google Books.
^Wildschut H, Both MI, Medema S, Thomee E, Wildhagen MF, Kapp N (January 2011). "Medical methods for mid-trimester termination of pregnancy". The Cochrane Database of Systematic Reviews. 2011 (1): CD005216. doi:10.1002/14651858.CD005216.pub2. PMC 8557267. PMID 21249669.
^"Mifepristone Use During Pregnancy". Drugs.com. 20 January 2023. Archived from the original on 23 April 2023. Retrieved 22 April 2023.
^Corey EJ, Czakó B, Kürti L (2012). "Mifepristone". Molecules and Medicine. John Wiley & Sons. ISBN 978-1-118-36173-3. Archived from the original on 8 September 2017 – via Google Books.
^"Drug Approval Package: Mifeprex (Mifepristone) NDA #20687". U.S. Food and Drug Administration (FDA). 18 June 2001. Archived from the original on 21 April 2023. Retrieved 24 April 2023.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^"Mifepristone Product information". Health Canada. 22 October 2009. Archived from the original on 24 April 2023. Retrieved 24 April 2023.
^Kingston A (5 February 2017). "How the arrival of the abortion pill reveals a double standard". Maclean's. Archived from the original on 21 February 2017. Retrieved 21 February 2017.
Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about a medical abortion during pregnancy and...
are most commonly performed by administering a two-drug combination: mifepristone followed by misoprostol. Evidence suggests this two-drug combination...
deaths. Modern methods use medication or surgery for abortions. The drug mifepristone in combination with prostaglandin appears to be as safe and effective...
developed, but only three, mifepristone, lilopristone, and onapristone, have been given to humans, and of these, only mifepristone has been approved and introduced...
Self-managed medical abortion is done with mifepristone and misoprostol at home before the 12th week of pregnancy. Mifepristone and misoprostol terminate the pregnancy...
Food and Drug Administration (FDA)'s approval of abortion medication mifepristone in 2000, and had issued a preliminary ruling suspending the approval...
(levonorgestrel, LNG) pills; and antiprogestin (ulipristal acetate or mifepristone) pills. Progestin-only and anti-progestin pills are available as specifically...
RU-42633; also known as desmethylmifepristone) is the major metabolite of mifepristone (RU-486, RU-38486) and a selective progesterone receptor modulator (SPRM)...
psychotic depression. There is no evidence for or against the use of mifepristone. There is some evidence indicating that combination therapy with an antidepressant...
drugs (NSAID). For abortions it is used by itself or in conjunction with mifepristone or methotrexate. By itself, effectiveness for abortion is between 66%...
Levonorgestrel, sold under the brand name Plan B Ulipristal acetate Mifepristone and misoprostol, when used in combination, are more than 95% effective...
much lower doses (30 mg) than the roughly equipotent mifepristone (600 mg), and since mifepristone has to be combined with a prostaglandin for the induction...
RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in...
work as a harm reduction strategy designed to provide safe access to mifepristone and misoprostol for those able to become pregnant in the United States...
and has therefore superseded the Yuzpe method. A single dose of 100 mg mifepristone is also more effective than the Yuzpe regime. The method was first developed...
Administration to use all means possible to preserve FDA approval for Mifepristone and protect access to these treatments nationwide, in response to a ruling...
Common abortifacients used in performing medical abortions include mifepristone, which is typically used in conjunction with misoprostol in a two-step...
glucocorticoid receptor antagonists, chemist Georges Teutsch synthesized mifepristone (RU-38486, the 38,486th compound synthesized by Roussel-Uclaf from 1949...
rate of 45 for every 1,000 women of reproductive age. Despite the law, mifepristone and misoprostol can be purchased under the table at many pharmacies....
these setting or count abortions induced by prescription drugs such as mifepristone and misoprostol taken at home, and so these official rates of abortion...
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