"DLB" redirects here. For other uses, see DLB (disambiguation).
Not to be confused with Lewy body dementia, an umbrella term encompassing Parkinson's disease dementia and dementia with Lewy bodies.
Medical condition
Dementia with Lewy bodies
Other names
Diffuse Lewy body disease, dementia due to Lewy body disease
Microscopic image of a Lewy body (arrowhead) in a neuron of the substantia nigra; scale bar=20 microns (0.02 mm)
Specialty
Neurology, psychiatry
Symptoms
Dementia, abnormal behavior during REM sleep, fluctuations in alertness, visual hallucinations, parkinsonism[1]
Usual onset
After the age of 50,[2] median 76[3]
Duration
Long term[4]
Causes
Unknown[4]
Diagnostic method
Based on symptoms and biomarkers[1]
Differential diagnosis
Alzheimer's, Parkinson's disease dementia, certain mental illnesses, vascular dementia[5]
Medication
Donepezil, rivastigmine and memantine;[6] melatonin[7]
Prognosis
Variable; average survival 4 years from diagnosis[8]
Frequency
About 0.4% of persons older than 65[9]
Dementia with Lewy bodies (DLB) is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. Memory loss is not always an early symptom. The disease worsens over time and is usually diagnosed when cognitive impairment interferes with normal daily functioning. Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias. It is a common form of dementia, but the prevalence is not known accurately and many diagnoses are missed. The disease was first described on autopsy by Kenji Kosaka in 1976, and he named the condition several years later.
REM sleep behavior disorder (RBD)—in which people lose the muscle paralysis (atonia) that normally occurs during REM sleep and act out their dreams—is a core feature. RBD may appear years or decades before other symptoms. Other core features are visual hallucinations, marked fluctuations in attention or alertness, and parkinsonism (slowness of movement, trouble walking, or rigidity). A presumptive diagnosis can be made if several disease features or biomarkers are present; the diagnostic workup may include blood tests, neuropsychological tests, imaging, and sleep studies. A definitive diagnosis usually requires an autopsy.
Most people with DLB do not have affected family members, although occasionally DLB runs in a family. The exact cause is unknown but involves formation of abnormal clumps of protein in neurons throughout the brain. Manifesting as Lewy bodies (discovered in 1912 by Frederic Lewy) and Lewy neurites, these clumps affect both the central and the autonomic nervous systems. Heart function and every level of gastrointestinal function—from chewing to defecation—can be affected, constipation being one of the most common symptoms. Low blood pressure upon standing can also occur. DLB commonly causes psychiatric symptoms, such as altered behavior, depression, or apathy.
DLB typically begins after the age of fifty,[2] and people with the disease have an average life expectancy, with wide variability, of about four years after diagnosis.[8] There is no cure or medication to stop the disease from progressing, and people in the latter stages of DLB may be unable to care for themselves. Treatments aim to relieve some of the symptoms and reduce the burden on caregivers. Medicines such as donepezil and rivastigmine can temporarily improve cognition and overall functioning, and melatonin can be used for sleep-related symptoms. Antipsychotics are usually avoided, even for hallucinations, because severe reactions occur in almost half of people with DLB,[10] and their use can result in death. Management of the many different symptoms is challenging, as it involves multiple specialties and education of caregivers.
^ abMcKeith et al. 2017, Table 1, p. 90.
^ ab"Lewy body dementia: Hope through research". National Institute of Neurological Disorders and Stroke. US National Institutes of Health. January 10, 2020. Archived from the original on April 30, 2021. Retrieved March 18, 2020.
^Hershey & Coleman-Jackson 2019, p. 309.
^ ab"Dementia with Lewy bodies information page". National Institute of Neurological Disorders and Stroke. March 27, 2019. Archived from the original on March 18, 2021. Retrieved March 18, 2020.
^Gomperts 2016, p. 437.
^Watts et al. 2022, p. 206.
^Taylor et al. 2020, sec. "Sleep disturbances".
^ abArmstrong 2021, sec. "Progression".
^Levin et al. 2016, p. 62.
^Taylor et al. 2020, sec. "Neuropsychiatric symptoms".
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