Psychosis induced by chronic treatment with neuroleptics
Dopamine supersensitivity psychosis is a hypothesis that attempts to explain the phenomenon in which psychosis (e.g. having hallucinations, which can mean hearing or seeing things that other people do not see or hear) occurs despite treatment with escalating doses of antipsychotics.[1] Dopamine supersensitivity may be caused by the dopamine receptor D2 antagonizing effect of antipsychotics, causing a compensatory increase in D2 receptors within the brain that sensitizes neurons to endogenous release of the neurotransmitter dopamine. Because psychosis is thought to be mediated—at least in part—by the activity of dopamine at D2 receptors, the activity of dopamine in the presence of supersensitivity may paradoxically give rise to worsening psychotic symptoms despite antipsychotic treatment at a given dose. This phenomenon may co-occur with tardive dyskinesia, a rare movement disorder that may also be due to dopamine supersensitivity.
^Nakata, Y; Kanahara, N; Iyo, M (December 2017). "Dopamine supersensitivity psychosis in schizophrenia: Concepts and implications in clinical practice". Journal of Psychopharmacology. 31 (12): 1511–1518. doi:10.1177/0269881117728428. PMID 28925317. S2CID 1957881.
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PMID 23870705. Nakata Y, Kanahara N, Iyo M (December 2017). "Dopaminesupersensitivitypsychosis in schizophrenia: Concepts and implications in clinical practice"...
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antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
result primarily from neuroleptic-induced dopaminesupersensitivity in the nigrostriatal pathway, with the D2 dopamine receptor being most affected. Neuroleptics...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
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antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivitypsychosis) and withdrawal-related relapse"...
such as dopaminesupersensitivity (DSS), glutamate or serotonin dysfunction, inflammation and oxidative stress. Studies have found that dopamine supersensitivity...
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