Global Information Lookup Global Information

Flupentixol information


Flupentixol
Clinical data
Trade namesDepixol, Fluanxol
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • AU: C
Routes of
administration
Oral, IM (including a depot)
Drug classTypical antipsychotic
ATC code
  • N05AF01 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • BR: Class C1 (Other controlled substances)[1]
  • CA: ℞-only
  • UK: POM (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability40–55% (oral)[2]
MetabolismGut wall, hepatic[4]
Elimination half-life35 hours[2]
ExcretionRenal (negligible)[3]
Identifiers
IUPAC name
  • (EZ)-2-[4-[3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
CAS Number
  • 2709-56-0 checkY
PubChem CID
  • 5281881
IUPHAR/BPS
  • 968
DrugBank
  • DB00875 ☒N
ChemSpider
  • 4445173 checkY
UNII
  • 21HMQ851IS
KEGG
  • D01044 checkY
ChEMBL
  • ChEMBL42055 ☒N
CompTox Dashboard (EPA)
  • DTXSID3058749 Edit this at Wikidata
ECHA InfoCard100.018.459 Edit this at Wikidata
Chemical and physical data
FormulaC23H25F3N2OS
Molar mass434.52 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • FC(F)(F)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(CCO)CC4
InChI
  • InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5- checkY
  • Key:NJMYODHXAKYRHW-DVZOWYKESA-N checkY
 ☒NcheckY (what is this?)  (verify)

Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol is a typical antipsychotic drug of the thioxanthene class. It was introduced in 1965 by Lundbeck. In addition to single drug preparations, it is also available as flupentixol/melitracen—a combination product containing both melitracen (a tricyclic antidepressant) and flupentixol (marketed as Deanxit). Flupentixol is not approved for use in the United States. It is, however, approved for use in the UK,[5] Australia,[6] Canada, Russian Federation,[7] South Africa, New Zealand, Philippines, Iran, Germany, and various other countries.

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ a b "Depixol Tablets 3mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Lundbeck Ltd. 27 December 2012. Retrieved 20 October 2013.
  3. ^ Balant-Gorgia AE, Balant L (August 1987). "Antipsychotic drugs. Clinical pharmacokinetics of potential candidates for plasma concentration monitoring". Clinical Pharmacokinetics. 13 (2): 65–90. doi:10.2165/00003088-198713020-00001. PMID 2887326. S2CID 24707620.
  4. ^ Jann MW, Ereshefsky L, Saklad SR (July–August 1985). "Clinical pharmacokinetics of the depot antipsychotics". Clinical Pharmacokinetics. 10 (4): 315–333. doi:10.2165/00003088-198510040-00003. PMID 2864156. S2CID 12848774.
  5. ^ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.
  6. ^ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
  7. ^ "Fluanxol® (flupentixol) Tablets Registration Certificate". Russian State Register of Medicinal Products. Retrieved 29 July 2014.

and 26 Related for: Flupentixol information

Request time (Page generated in 0.5803 seconds.)

Flupentixol

Last Update:

Flupentixol (INN), also known as flupenthixol (former BAN), marketed under brand names such as Depixol and Fluanxol is a typical antipsychotic drug of...

Word Count : 2454

List of antipsychotics

Last Update:

sorted by class. Bromperidol decanoate Clopenthixol decanoate Flupentixol decanoate Flupentixol palmitate Fluphenazine decanoate Fluphenazine enanthate Haloperidol...

Word Count : 49

Melitracen

Last Update:

marketed by Lundbeck, a combination product containing both melitracen and flupentixol. The pharmacology of melitracen has not been properly investigated and...

Word Count : 381

Ketamine

Last Update:

Antagonists Typical antipsychotics: Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline)...

Word Count : 11403

LSD

Last Update:

Antagonists Typical antipsychotics: Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline)...

Word Count : 16528

Brazilian Controlled Drugs and Substances Act

Last Update:

Phenelzine Pheniprazine Phenytoin Fluphenazine Flumazenil Fluoxetine Flupentixol Fluvoxamine Gabapentin Galantamine Haloperidol Halothane Chloral hydrate...

Word Count : 1685

Zuclopenthixol

Last Update:

100 mg of zuclopenthixol decanoate is roughly equivalent to 20 mg of flupentixol decanoate or 12.5 mg of fluphenazine decanoate. In oral form zuclopenthixol...

Word Count : 1776

List of antidepressants

Last Update:

Amitriptyline/perphenazine (Etafron) – TCA and typical antipsychotic combination Flupentixol/melitracen (Deanxit) – TCA and typical antipsychotic combination Olanzapine/fluoxetine...

Word Count : 1411

Piperazine

Last Update:

Meclizine Niaprazine Antiserotonergics EGIS-7625 Antipsychotics Typical Flupentixol Fluphenazine Perphenazine Prochlorperazine Thiothixene Trifluoperazine...

Word Count : 1618

Alprazolam

Last Update:

Bupropion Tianeptine Vilazodone Vortioxetine Antipsychotics Quetiapine Flupentixol Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2...

Word Count : 8228

Schizophrenia

Last Update:

first-generation antipsychotics, now called typical antipsychotics like Flupentixol, are dopamine antagonists that block D2 receptors, and affect the neurotransmission...

Word Count : 18392

Parkinsonism

Last Update:

phenothiazines (such as perphenazine and chlorpromazine), thioxanthenes (such as flupentixol and zuclopenthixol) and butyrophenones (such as haloperidol), and rarely...

Word Count : 2303

Sertraline

Last Update:

Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone...

Word Count : 10585

Trazodone

Last Update:

Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone...

Word Count : 9966

Aripiprazole

Last Update:

Sordinol Depot Typical Viscoleob 50–600 mg/1–4 weeks 4–7 days ? 19 days 9.0 Flupentixol decanoate Depixol Typical Viscoleob 10–200 mg/2–4 weeks 4–10 days 8 days...

Word Count : 9149

Gabapentin

Last Update:

Bupropion Tianeptine Vilazodone Vortioxetine Antipsychotics Quetiapine Flupentixol Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2...

Word Count : 8581

Fluoxetine

Last Update:

Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone...

Word Count : 11667

Pregabalin

Last Update:

Bupropion Tianeptine Vilazodone Vortioxetine Antipsychotics Quetiapine Flupentixol Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2...

Word Count : 8575

Promethazine

Last Update:

Antagonists Typical antipsychotics: Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline)...

Word Count : 2681

Venlafaxine

Last Update:

Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone...

Word Count : 6503

Bupropion

Last Update:

Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone...

Word Count : 10324

Citalopram

Last Update:

Dextromethorphan/bupropion Esketamine Etryptamine‡ Gepirone Indeloxazine Flupentixol Ketamine§ Medifoxamine‡ Metryptamine‡ Oxaflozane‡ Pivagabine‡ Tandospirone...

Word Count : 4585

Psychiatry

Last Update:

Thioxanthenes: Chlorprothixene Clopenthixol Clopenthixol decanoate Flupentixol Flupentixol decanoate Tiotixene (thiothixene) Zuclopenthixol Zuclopenthixol...

Word Count : 10343

Benzamide

Last Update:

Thioxanthenes: Chlorprothixene Clopenthixol Clopenthixol decanoate Flupentixol Flupentixol decanoate Tiotixene (thiothixene) Zuclopenthixol Zuclopenthixol...

Word Count : 384

ATC code N05

Last Update:

Molindone N05AE03 Sertindole N05AE04 Ziprasidone N05AE05 Lurasidone N05AF01 Flupentixol N05AF02 Clopenthixol N05AF03 Chlorprothixene N05AF04 Thiothixene N05AF05...

Word Count : 591

Chlordiazepoxide

Last Update:

Bupropion Tianeptine Vilazodone Vortioxetine Antipsychotics Quetiapine Flupentixol Sympatholytics (Antiadrenergics) Alpha-1 blockers (e.g., prazosin) Alpha-2...

Word Count : 3167

PDF Search Engine © AllGlobal.net