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The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The model draws evidence from the observation that a large number of antipsychotics have dopamine-receptor antagonistic effects. The theory, however, does not posit dopamine overabundance as a complete explanation for schizophrenia. Rather, the overactivation of D2 receptors, specifically, is one effect of the global chemical synaptic dysregulation observed in this disorder.
and 29 Related for: Dopamine hypothesis of schizophrenia information
hypothesis of schizophreniaDopaminehypothesisof stuttering This disambiguation page lists articles associated with the title Dopaminehypothesis. If an internal...
dopaminehypothesisofschizophrenia, which postulates that schizophrenia is largely caused by hyperactivity of brain dopamine systems. The dopamine hypothesis...
The first formulations of the dopaminehypothesisofschizophrenia came from post-mortem studies finding increased numbers of D2/D3 receptors in the striatum...
forward was the dopaminehypothesisofschizophrenia, which attributes psychosis to the mind's faulty interpretation of the misfiring of dopaminergic neurons...
thought to be more proximal to the root causes ofschizophrenia, it does not negate the dopaminehypothesis, and the two may be ultimately brought together...
"History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopaminehypothesisofschizophrenia". Journal of the History of the Neurosciences...
Stahl SM (June 2018). "Beyond the dopaminehypothesisofschizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate". CNS Spectrums...
neurotransmitter". This led to the dopamine hypothesisofschizophrenia. Animal studies provide evidence that estrogen regulates dopamine systems. In the studies performed...
increased dopamine release after treatment with amphetamine relative to normal controls. In the dopaminehypothesisofschizophrenia, schizophrenia was hypothesised...
dopamine hypothesisofschizophrenia. Despite the controversy, dopamine antagonists remain a standard and successful treatment for schizophrenia. These...
the promoter region of the DRD4 gene. This gene codes for the dopamine receptor D4. Due to the dopaminehypothesisofschizophrenia the SNP has been investigated...
discovered the dopamine D2 receptor, the basis for the dopaminehypothesisofschizophrenia. In 2001, he was made an Officer of the Order of Canada "for...
networks of procedural memory. To learn more about the effects ofdopamine and its role in schizophrenia see: dopaminehypothesisofschizophrenia. Studies...
believed to be responsible for some symptoms ofschizophrenia (known as the dopaminehypothesisofschizophrenia), amphetamines may worsen psychotic symptoms...
creation and function ofdopamine transmission. Another, less accepted, theory that explains the connection between famine and schizophrenia is protein-calorie...
second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are...
Dopamine supersensitivity psychosis is a hypothesis that attempts to explain the phenomenon in which psychosis (e.g. having hallucinations, which can...
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. The structure of DRD4 has...
with schizophrenia. Further, the expression ofdopamine receptors has indeed been shown to be regulated by retinoic acid. Isotretinoin has a number of muscoloskeletal...
pathogenesis ofschizophrenia. The kynurenic acid hypothesisofschizophrenia was proposed in 2007, based on its action on midbrain dopamine activity and...
effect in schizophrenia, and that the term "tranquiliser" is a misnomer' using the term anti-schizophrenic, discussing the dopaminehypothesis and by 1975...
onset of catatonia can be acute or subtle and symptoms can wax, wane, or change during episodes. It has historically been related to schizophrenia (catatonic...
caused by a biological process in the brain, such as the dopaminehypothesisofschizophrenia.[citation needed] Although pilot treatments since the 1980s...
Schizophrenia and tobacco smoking have been historically associated. Smoking is known to harm the health of people with schizophrenia. Studies across...
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