negative regulation of synaptic transmission, glutamatergic
response to hypoxia
negative regulation of circadian sleep/wake cycle, sleep
negative regulation of protein secretion
synapse assembly
regulation of locomotion involved in locomotory behavior
dopamine receptor signaling pathway
negative regulation of dopamine receptor signaling pathway
startle response
positive regulation of receptor internalization
protein localization
arachidonic acid secretion
positive regulation of transcription by RNA polymerase II
G protein-coupled receptor internalization
positive regulation of multicellular organism growth
positive regulation of long-term synaptic potentiation
negative regulation of dopamine secretion
adult behavior
cerebral cortex GABAergic interneuron migration
regulation of synapse structural plasticity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
visual learning
negative regulation of cell migration
behavioral response to cocaine
positive regulation of neuroblast proliferation
negative regulation of blood pressure
release of sequestered calcium ion into cytosol
negative regulation of voltage-gated calcium channel activity
G protein-coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
excitatory postsynaptic potential
negative regulation of protein phosphorylation
autophagy
positive regulation of neurogenesis
negative regulation of cell death
drinking behavior
adrenergic receptor signaling pathway
regulation of neurotransmitter uptake
postsynaptic modulation of chemical synaptic transmission
regulation of synaptic vesicle exocytosis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1813
13489
Ensembl
ENSG00000149295
ENSMUSG00000032259
UniProt
P14416
P61168
RefSeq (mRNA)
NM_016574 NM_000795
NM_010077
RefSeq (protein)
NP_000786 NP_057658 NP_000786.1
NP_034207
Location (UCSC)
Chr 11: 113.41 – 113.48 Mb
Chr 9: 49.25 – 49.32 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D2 receptor.[5] The dopamine D2 receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined.[6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000149295 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032259 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Madras BK (2013). "History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia". Journal of the History of the Neurosciences. 22 (1): 62–78. doi:10.1080/0964704X.2012.678199. PMID 23323533. S2CID 12002684.
^Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL (March 2018). "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone". Nature. 555 (7695): 269–273. Bibcode:2018Natur.555..269W. doi:10.1038/nature25758. PMC 5843546. PMID 29466326.
^"NIMH » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor". www.nimh.nih.gov. 29 January 2018. Retrieved 26 November 2018.
and 27 Related for: Dopamine receptor D2 information
DopaminereceptorD2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested...
The D1 and D5 receptors are members of the D1-like family of dopaminereceptors, whereas the D2, D3 and D4 receptors are members of the D2-like family....
and locomotor activity, mediating some behaviors and modulating dopaminereceptorD2-mediated events. They play a role in addiction by facilitating the...
to. The D1-like class of dopaminereceptors is coupled to Gαs/olf and stimulates adenylate cyclase production, whereas the D2-like class is coupled to...
A dopamine agonist (DA) is a compound that activates dopaminereceptors. There are two families of dopaminereceptors, D1-like and D2-like. They are all...
Dopaminereceptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopaminereceptor. The D3 subtype...
engagement at the dopaminereceptor (D2). Aripiprazole is a partial agonist at dopamineD2receptors, partial agonist at 5-HT1A receptors and an antagonist...
of the dopaminereceptorD2 plays a role in self-administration and the reinforcing effects of cocaine and other stimulants. The D2receptor availability...
antipsychotics. Dopamine supersensitivity may be caused by the dopaminereceptorD2 antagonizing effect of antipsychotics, causing a compensatory increase in D2 receptors...
Dopaminereceptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with...
area contains a large population of type D2dopaminereceptors. Consequently, drugs that activate D2receptors have a high potential to cause nausea. This...
and DRD5) or D2-type (i.e., DRD2, DRD3, and DRD4) dopaminereceptors. A subpopulation of MSNs contain both D1-type and D2-type receptors, with approximately 40%...
System DopaminereceptorD2, a protein Levuglandin D2 Prostaglandin D2receptor, a G-protein coupled receptor Resolvin D2 Cyclin D2 (CCND2) Vitamin D2, or...
on decreased levels of dopamine activity due to: Dopaminereceptor blockade Genetically reduced function of dopaminereceptorD2 Sympathoadrenal hyperactivity...
behavioural supersensitivity to dopamine and a marked rise in the number of dopamineD2receptors in the high-affinity state for dopamine. This latter work implies...
(300 μg/kg), the D2/D3 receptors were 94% occupied, while at the lowest dose (1 μg/kg), receptors were 5% occupied. DopamineD2 and D3 receptor occupancy in...
A2A receptor has been shown to interact with DopaminereceptorD2. As a result, Adenosine receptor A2A decreases activity in the DopamineD2receptors. The...
prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. Also known as PTGDR or DP receptors, they are...
taken by mouth. Cabergoline is an ergot derivative and a potent dopamineD2receptor agonist. Cabergoline was patented in 1980 and approved for medical...
disorders. Dopamine is now one of the primary neurotransmitters implicated in psychotic symptomology. Blocking dopaminereceptors (namely, the dopamineD2 receptors)...
stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopaminereceptorD2. It also inhibits the neuronal re-uptake of norepinephrine...
evidence indicates abnormal dopaminereceptorD2 structure, as well as a reduced link between dopaminereceptor D1 and receptorD2. Studies have shown that...
interval timing, whereas antagonists of D2 type dopaminereceptors typically slow timing;... Depletion of dopamine in healthy volunteers impairs timing,...
agonist of the dopamineD2receptor. It also interacts with other dopaminereceptors and with various serotonin and adrenergic receptors. Bromocriptine...
D2receptor of 60%+, brexpiprazole has an intrinsic activity at the same receptor of about 45%. For aripiprazole, this means more dopaminereceptor activation...
Global Information
