regulation of postsynaptic neurotransmitter receptor internalization
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
G protein-coupled serotonin receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1815
13491
Ensembl
ENSG00000069696 ENSG00000276825
ENSMUSG00000025496
UniProt
P21917
P51436
RefSeq (mRNA)
NM_000797
NM_007878
RefSeq (protein)
NP_000788
NP_031904
Location (UCSC)
Chr 11: 0.64 – 0.64 Mb
Chr 7: 140.87 – 140.88 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5.[5]
The structure of DRD4 has been reported in complex with the antipsychotic drug nemonapride.[6]
As with other dopamine receptor subtypes, the D4 receptor is activated by the neurotransmitter dopamine. It is linked to many neurological and psychiatric conditions[7] including schizophrenia and bipolar disorder,[8] ADHD,[9][10] addictive behaviors,[11] Parkinson's disease,[12] and eating disorders such as anorexia nervosa.[13] A weak association has been drawn between DRD4 and borderline personality disorder.
It is also a target for drugs which treat schizophrenia and Parkinson's disease.[14] The D4 receptor is considered to be D2-like in which the activated receptor inhibits the enzyme adenylate cyclase, thereby reducing the intracellular concentration of the second messenger cyclic AMP.[15]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025496 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (April 1991). "Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine". Nature. 350 (6319): 610–4. Bibcode:1991Natur.350..610V. doi:10.1038/350610a0. PMID 1840645. S2CID 4244670.
multiple types of receptors for dopamine was first proposed in 1976. There are at least five subtypes of dopaminereceptors, D1, D2, D3, D4, and D5. The D1...
dopamine antagonist, also known as an anti-dopaminergic and a dopaminereceptor antagonist (DRA), is a type of drug which blocks dopaminereceptors by...
Dopaminereceptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested...
Carcinoma in situ of skin ICD-10 code DopaminereceptorD4, a human gene Octamethylcyclotetrasiloxane, called D4 Dihedral group of order 4, otherwise known...
protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the D2-like family includes D2, D3 and D4receptors. Dopamine agonists are...
Dopaminereceptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopaminereceptor. The D3 subtype...
receptors are the most numerous dopaminereceptors in the human nervous system; D2 receptors are next; D3, D4, and D5 receptors are present at significantly...
there may be a link to genetics. Studies have found an area on the DopaminereceptorD4 gene on chromosome 11 that is characterized by several repeats in...
Dopaminereceptor D1, also known as DRD1. It is one of the two types of D1-like receptor family — receptors D1 and D5. It is a protein that in humans...
non-selective agonist of the dopamine D1, D2, D3, and, to a lesser extent, D4 and D5 receptors, with highest affinity for the D3 receptor. In terms of affinity...
promoter region of the DRD4 gene. This gene codes for the dopaminereceptorD4. Due to the dopamine hypothesis of schizophrenia the SNP has been investigated...
Dopaminereceptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with...
found to be linked with a gene orthologous to the human gene DRD4 (DopaminereceptorD4) which is known to be associated with novelty-seeking behaviour....
scrutiny as of 2012[update], the DRD4 7-repeat polymorphism (of the dopaminereceptorD4) located on chromosome 11 has been linked to disorganized attachment...
large number of antipsychotics have dopamine-receptor antagonistic effects. The theory, however, does not posit dopamine overabundance as a complete explanation...
D3 receptors, serotonin 5-HT1A and 5-HT1D receptors, and α2A-, α2B-, and α2C-adrenergic receptors, and low-nanomolar affinity for the dopamine D1, D4, and...
variant of dopaminereceptorD4 (DRD4–7R) causes increased inhibitory effects induced by dopamine and is associated with ADHD. The DRD4 receptor is a G protein-coupled...
with dopaminereceptors (partial agonist activity on postsynaptic D2 receptor and partial agonist activity on presynaptic D2, D3 and partially D4) and...
taken by mouth. Cabergoline is an ergot derivative and a potent dopamine D2 receptor agonist. Cabergoline was patented in 1980 and approved for medical...
depressive disorder. Both generations of medication tend to block receptors in the brain's dopamine pathways. Atypicals are less likely than haloperidol—the most...
executive functions is among the highest of any psychological trait. The dopaminereceptorD4 gene (DRD4) with 7'-repeating polymorphism (7R) has been repeatedly...
7-repeat variant of the dopaminereceptorD4 gene had higher scores of self-reported extraversion. This suggests that dopamine and serotonin interact to...
phenotypes. For example, both 7R and 5R, ADHD-linked VNTR alleles of dopaminereceptorD4 gene are directly associated with the incidence of proactive aggression...
for the dopamine D2, D3, and D4receptors (Ki > 10,000 nM) and does not appear to have significant affinity for the α1-adrenergic receptors.[additional...