protein serine/threonine phosphatase inhibitor activity
protein kinase inhibitor activity
protein binding
cAMP-dependent protein kinase inhibitor activity
protein phosphatase regulator activity
protein phosphatase inhibitor activity
D1 dopamine receptor binding
D2 dopamine receptor binding
D3 dopamine receptor binding
D4 dopamine receptor binding
D5 dopamine receptor binding
Cellular component
cytoplasm
neuronal cell body
nucleus
cytosol
dendritic spine neck
dendritic spine head
postsynapse
glutamatergic synapse
Biological process
visual learning
intracellular signal transduction
response to amphetamine
transcription, DNA-templated
negative regulation of female receptivity
signal transduction
negative regulation of protein kinase activity
negative regulation of protein serine/threonine kinase activity
negative regulation of phosphoprotein phosphatase activity
locomotory behavior
response to morphine
behavioral response to cocaine
response to cocaine
memory
response to nicotine
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
84152
19049
Ensembl
ENSG00000131771
ENSMUSG00000061718
UniProt
Q9UD71
Q60829
RefSeq (mRNA)
NM_001242464 NM_032192 NM_181505
NM_144828 NM_001313970
RefSeq (protein)
NP_001229393 NP_115568 NP_852606 NP_115568.2
NP_001300899 NP_659077
Location (UCSC)
Chr 17: 39.63 – 39.64 Mb
Chr 11: 98.24 – 98.25 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000131771 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000061718 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)".
^Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (March 1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". The Journal of Neuroscience. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene...
is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". Int. J. Oncol. 24 (4): 757–63. doi:10.3892/ijo.24...
is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". Int. J. Oncol. 24 (4): 757–63. doi:10.3892/ijo.24...
is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". International Journal of Oncology. 24 (4): 757–63...
is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". International Journal of Oncology. 24 (4): 757–63...