Diazoxide, sold under the brand name Proglycem and others, is a medication used to treat low blood sugar due to a number of specific causes.[2] This includes islet cell tumors that cannot be removed and leucine sensitivity.[2] It can also be used in refractory cases of sulfonylurea toxicity.[3] It is generally taken by mouth.[2]
Common side effects include high blood sugar, fluid retention, low blood platelets, a fast heart rate, increased hair growth, and nausea.[2] Other severe side effects include pulmonary hypertension and heart failure.[2] It is chemically similar to thiazide diuretics.[2] It works by decreasing insulin release from the pancreas and increasing glucose release by the liver.[2]
Diazoxide was approved for medical use in the United States in 1973.[2] It is on the World Health Organization's List of Essential Medicines.[4][5] It is available as a generic medication.[6]
^"Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
^ abcdefgh"Diazoxide Monograph for Professionals". Drugs.com. Retrieved 11 October 2019.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 708. ISBN 9780857113382.
Diazoxide, sold under the brand name Proglycem and others, is a medication used to treat low blood sugar due to a number of specific causes. This includes...
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subsequently also marketed in Europe and Japan. Related drugs include diazoxide, hydrochlorothiazide, and chlorothiazide. In 1993, it was discovered that...