Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure.[2] This includes high blood pressure in pregnancy and very high blood pressure resulting in symptoms.[3] It has been found to be particularly useful in heart failure, together with isosorbide dinitrate, for treatment of people of African descent.[2] It is given by mouth or by injection into a vein.[3] Effects usually begin around 15 minutes and last up to six hours.[2]
Common side effects include headache and fast heart rate.[2] It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve.[2] In those with kidney disease a low dose is recommended.[3] Hydralazine is in the vasodilator family of medications, so it is believed to work by causing the dilation of blood vessels.[2]
Hydralazine was discovered while scientists at Ciba were looking for a treatment for malaria.[4] It was patented in 1949.[5] It is on the World Health Organization's List of Essential Medicines.[6] In 2021, it was the 106th most commonly prescribed medication in the United States, with more than 6million prescriptions.[7][8]
^"Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
^ abcdefgh"Hydralazine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^ abcWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 280. hdl:10665/44053. ISBN 9789241547659.
^Wermuth CG (2 May 2011). The Practice of Medicinal Chemistry. Academic Press. p. 12. ISBN 9780080568775. Archived from the original on 26 February 2017.
^Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques. Birkhäuser. 2013. p. 206. ISBN 9783034870948. Archived from the original on 20 December 2016.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Hydralazine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Hydralazine, sold under the brand name Apresoline among others, is a medication used to treat high blood pressure and heart failure. This includes high...
(especially the arterioles), allowing the vessel to dilate (widen). hydralazine minoxidil Hydralazine may cause headaches, swelling around the eyes, heart palpitations...
particularly useful in heart failure due to systolic dysfunction together with hydralazine. It is taken by mouth or under the tongue. Common side effects include...
hydrazinophthalazine chemical class. It has very similar effects to hydralazine. Headache Loss of Appetite Nausea Vomiting Diarrhea Palpitations Increased...
chemistry after administration and can cause lymph node enlargement. Hydralazine and Allopurinol are medications that are prescribed to patients to lower...
one of the metabolic products of the antihypertensive pharmaceutical hydralazine, and itself also have antihypertensive effects. "Acetone hydrazone"....
used agents are ACE inhibitors and hydralazine. Studies have shown that the use of ACE inhibitors and hydralazine can delay surgical treatment of MR....
Hydrazinophthalazines are a class of antihypertensive drugs including: Hydralazine Dihydralazine Cadralazine Endralazine Chemically, the latter two aren't...
ARB or who have significant kidney dysfunction, the use of combined hydralazine and a long-acting nitrate, such as isosorbide dinitrate, is an effective...
González-Fierro A, Trejo-Becerril C, Taja-Chayeb L, et al. (April 2011). "Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome...
discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over...
beta-adrenergic blockade in hypertension. A comparative study of minoxidil and hydralazine". Circulation. 45 (3): 571–582. doi:10.1161/01.CIR.45.3.571. PMID 4401051...
Cancer Side effect of some medications, e.g. isoniazid, cyclosporine, hydralazine, warfarin, and heparin Radiation induced Aortic dissection Postpericardiotomy...
several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. In the course of his classic investigation on the Fischer indole synthesis...
effective of which were tetramethylammonium chloride, hexamethonium, hydralazine, and reserpine (derived from the medicinal plant Rauvolfia serpentina)...
p-aminobenzoic acid). Some haptens can induce autoimmune disease. An example is hydralazine, a blood pressure-lowering drug that occasionally can produce drug-induced...
demonstrates tachyphylaxis, requiring drug-free intervals of 6 to 8 hours. Hydralazine displays tachyphylaxis if given as a monotherapy for antihypertensive...
generally safe. Treatment options include blood pressure medications such as hydralazine and emergency delivery of the baby either vaginally or by cesarean section...
these landmark trials include: V-HeFT (1986) — use of vasodilators (hydralazine & isosorbide dinitrate) in heart failure ISIS-2 (1988) — use of aspirin...
Gyromitrin is metabolized into monomethyl hydrazine. Isoniazid, iproniazid, hydralazine, and phenelzine are medications whose molecules contain hydrazine-like...
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