double-strand break repair via alternative nonhomologous end joining
negative regulation of mitochondrial DNA replication
cellular response to DNA damage stimulus
cell division
DNA ligation
DNA replication
double-strand break repair via homologous recombination
V(D)J recombination
DNA ligation involved in DNA repair
cell cycle
transcription-coupled nucleotide-excision repair
double-strand break repair
DNA repair
base-excision repair, DNA ligation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3980
16882
Ensembl
ENSG00000005156
ENSMUSG00000020697
UniProt
P49916
P97386
RefSeq (mRNA)
NM_002311 NM_013975
NM_001291245 NM_001291246 NM_001291247 NM_010716
RefSeq (protein)
NP_002302 NP_039269
n/a
Location (UCSC)
Chr 17: 34.98 – 35.01 Mb
Chr 11: 82.67 – 82.7 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DNA ligase 3 also DNA ligase III, is an enzyme that, in humans, is encoded by the LIG3 gene.[5][6]LIG3 encodes ATP-dependent DNA ligases that seal interruptions in the phosphodiester backbone of duplex DNA.
There are three families of ATP-dependent DNA ligases in eukaryotes.[7] These enzymes utilize the same three step reaction mechanism; (i) formation of a covalent enzyme-adenylate intermediate; (ii) transfer of the adenylate group to the 5' phosphate terminus of a DNA nick; (iii) phosphodiester bond formation. Unlike LIG1 and LIG4 family members that are found in almost all eukaryotes, LIG3 family members are less widely distributed.[8]LIG3 encodes several distinct DNA ligase species by alternative translation initiation and alternative splicing mechanisms that are described below.
^ abcGRCh38: Ensembl release 89: ENSG00000005156 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020697 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Ligase III, DNA, ATP-dependent". Retrieved 2012-03-12.
^Tomkinson AE, Sallmyr A (December 2013). "Structure and function of the DNA ligases encoded by the mammalian LIG3 gene". Gene. 531 (2): 150–7. doi:10.1016/j.gene.2013.08.061. PMC 3881560. PMID 24013086.
^Simsek D, Jasin M (November 2011). "DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested". Cell Cycle. 10 (21): 3636–44. doi:10.4161/cc.10.21.18094. PMC 3266004. PMID 22041657.
DNAligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role...
DNAligase3 also DNAligase III, is an enzyme that, in humans, is encoded by the LIG3 gene. LIG3 encodes ATP-dependent DNAligases that seal interruptions...
DNAligase 4 also DNAligase IV, is an enzyme that in humans is encoded by the LIG4 gene. DNAligase 4 is an ATP-dependent DNAligase that joins double-strand...
ligases include the word "ligase", such as in DNAligase, an enzyme commonly used in molecular biology laboratories to join together DNA fragments. However,...
discontinuously and later linked together by the enzyme DNAligase to create the lagging strand during DNA replication. They were discovered in the 1960s by...
E3 ligases regulates diverse areas such as cell trafficking, DNA repair, and signaling and is of profound importance in cell biology. E3 ligases are...
double-stranded DNA that originates in a linear form that is ligated by means of DNAligase to a covalently closed ring. In most cases, transcription of viral DNA can...
The ligase chain reaction (LCR) is a method of DNA amplification. The ligase chain reaction (LCR) is an amplification process that differs from PCR in...
linear DNA molecule with a 3' thymine overhang. Since adenine and thymine form a base pair, this facilitates the joining of the two molecules by a ligase, yielding...
Either DNA polymerase epsilon or DNA polymerase delta along with DNAligase can be used to repair UV-damaged DNA. However, it is found that DNA polymerase...
second component involves the bridging of DNA to DNAligase 4, by hXRCC4, with the aid of Cernunnos-XLF. DNA-PKcs and hXRCC4 are anchored to Ku70 / Ku80...
HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of...
Akira S, et al. (April 2014). "Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity". Proceedings of the National...
by ligation is a DNA sequencing method that uses the enzyme DNAligase to identify the nucleotide present at a given position in a DNA sequence. Unlike...
segment of DNA by polymerizing nucleotides, a concept which is applicable to numerous fields in modern biology and related sciences. Ligase chain reaction...
and DNA fingerprinting. Enzymes called DNAligases can rejoin cut or broken DNA strands. Ligases are particularly important in lagging strand DNA replication...
enzyme, DNAligase, fragments generated by restriction enzymes could be joined in new combinations, termed recombinant DNA. By recombining DNA segments...
artificial DNA primers can be used to start DNA synthesis at known sequences in a template DNA molecule. Polymerase chain reaction (PCR), ligase chain reaction...
E3A may refer to: Y-DNA haplogroup E3a Ubiquitin protein ligase E3A Boeing E-3 Sentry, an American military aircraft Minamikyushu Expressway, route E3A...
of a DNA strand with no attached complement) known as a sticky end on each end of AATT. The overhang can then be used to ligate in (see DNAligase) a piece...
eukaryotes, newly synthesized lagging-strand DNA transiently contains nicks (before being sealed by DNAligase) and provides a signal that directs mismatch...
replication fork, the gap in DNA after removal of the flap is sealed by DNAligase I, which repairs the nicks that are left between the 3'-OH and 5'phosphate of...
involved in DNA damage recognition of DNA double-strand breaks. Lysine 63-linked polyubiquitin chains are formed on H2AX histone by the E2/E3 ligase pair, Ubc13-Mms2/RNF168...
Global Information
