Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Stress granule dynamics
In cellular biology, stress granules are biomolecular condensates in the cytosol composed of proteins and RNAs that assemble into 0.1–2 μm membraneless organelles when the cell is under stress.[1][2][3] The mRNA molecules found in stress granules are stalled translation pre-initiation complexes associated with 40S ribosomal subunits, translation initiation factors, poly(A)+ mRNAs and RNA-binding proteins (RBPs). While they are membraneless organelles, stress granules have been proposed to be associated with the endoplasmatic reticulum.[4] There are also nuclear stress granules. This article is about the cytosolic variety.
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^Hirose T, Ninomiya K, Nakagawa S, Yamazaki T (April 2023). "A guide to membraneless organelles and their various roles in gene regulation". Nature Reviews. Molecular Cell Biology. 24 (4): 288–304. doi:10.1038/s41580-022-00558-8. PMID 36424481. S2CID 253879916.
^Hirose T, Ninomiya K, Nakagawa S, Yamazaki T (April 2023). "A guide to membraneless organelles and their various roles in gene regulation". Nature Reviews. Molecular Cell Biology. 24 (4): 288–304. doi:10.1038/s41580-022-00558-8. PMID 36424481. S2CID 253879916.
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In cellular biology, stressgranules are biomolecular condensates in the cytosol composed of proteins and RNAs that assemble into 0.1–2 μm membraneless...
response to stress, TIA1 translocates from the nucleus to the cytoplasm, where it nucleates a type of RNA granule, termed the stressgranule, and participates...
research on it. It has been shown to inhibit eIF2α phosphorylation-induced stressgranule (SG) formation. Since eIF2α phosphorylation is known to be involved...
neurofibrillary tangles) stimulates stressgranule formation. Importantly, the converse is also true. Stressgranules appear able to stimulate tau pathology...
center (MTOC) cytoskeleton flagellum nucleolus stressgranule germ cell granule neuronal transport granule The mechanisms by which such non-membrane bounded...
of water Standard gamble, a direct method to measure the QALY weight Stressgranule Shooting guard, a basketball position Sanspareils Greenlands, a cricket...
Hospital in Paul Anderson's lab, where her work focused on studying stressgranule formation. In late-2020, she retired. In addition to her contributions...
eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes:...
determined. G3BP1 can initiate stressgranule formation and labeled G3BP1 is commonly used as a marker for stressgranules. G3BP1 has been shown to interact...
granule cell has been used for a number of different types of neurons whose only common feature is that they all have very small cell bodies. Granule...
(March 1998). "Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress". Proc. Natl. Acad. Sci. U.S.A....
carcinoma cells, LIN28 is localized in the ribosomes, P-bodies and stressgranules. LIN28 is thought to regulate the self-renewal of stem cells. In Caenorhabditis...
weak intermolecular forces. MLOs are present in the cytoplasm (e.g. stressgranules, processing bodies) and in the nucleus (e.g. nucleolus, nuclear speckles)...
post-transcriptional fate of mRNAs. RNP granules are a highly diverse group of compartments. These include stressgranules, processing bodies, and exosomes in...
"Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles". Journal of Immunology. 156 (6): 2026–35. doi:10.4049/jimmunol...
gradient. Upon stress, several karyopherins stop shuttling between the nucleus and the cytoplasm and are sequestered in stressgranules, cytoplasmic aggregates...
heat-shock protein 90 (Hsp90). HDAC6 is required in the formation of stressgranule (SG) proteins and is instrumental in SG formation; pharmacological inhibition...
granules. Amino acid availability determines RPTOR targeting to lysosomes. In stressed cells, RPTOR associates with SPAG5 and accumulates in stress granules...
SS3, and GBSS, are critical for starch granule biosynthesis and play a catalytic role at each step of granule biogenesis and expansion. In addition to...
cytoplasm and concentrated at sites of high mRNA concentration such as stressgranules, processing bodies, and locations of high translational activity. PABPC1...
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