DNAligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role...
DNAligase4 also DNAligase IV, is an enzyme that in humans is encoded by the LIG4 gene. DNAligase4 is an ATP-dependent DNAligase that joins double-strand...
ligases include the word "ligase", such as in DNAligase, an enzyme commonly used in molecular biology laboratories to join together DNA fragments. However,...
second component involves the bridging of DNA to DNAligase4, by hXRCC4, with the aid of Cernunnos-XLF. DNA-PKcs and hXRCC4 are anchored to Ku70 / Ku80...
DNAligase 3 also DNAligase III, is an enzyme that, in humans, is encoded by the LIG3 gene. LIG3 encodes ATP-dependent DNAligases that seal interruptions...
discontinuously and later linked together by the enzyme DNAligase to create the lagging strand during DNA replication. They were discovered in the 1960s by...
double-stranded DNA that originates in a linear form that is ligated by means of DNAligase to a covalently closed ring. In most cases, transcription of viral DNA can...
The ligase chain reaction (LCR) is a method of DNA amplification. The ligase chain reaction (LCR) is an amplification process that differs from PCR in...
Either DNA polymerase epsilon or DNA polymerase delta along with DNAligase can be used to repair UV-damaged DNA. However, it is found that DNA polymerase...
several proteins including ligase4, DNA polymerase mu and NHEJ factor 1 (NHEJ1, also known as Cernunnos or XLF). DNAligase4 (Lig4) has a highly specific...
of DNA repair and response pathways that depends on HSC quiescence. DNAligase4 (Lig4) has a highly specific role in the repair of double-strand breaks...
E3 ligases regulates diverse areas such as cell trafficking, DNA repair, and signaling and is of profound importance in cell biology. E3 ligases are...
Blunt ends are not always desired in biotechnology since when using a DNAligase to join two molecules into one, the yield is significantly lower with...
enzyme, DNAligase, fragments generated by restriction enzymes could be joined in new combinations, termed recombinant DNA. By recombining DNA segments...
segment of DNA by polymerizing nucleotides, a concept which is applicable to numerous fields in modern biology and related sciences. Ligase chain reaction...
major NHEJ factor X4L4 (XRCC4-DNAligase4 complex). X4L4 stimulates WRN exonuclease activity that likely facilitates DNA end processing prior to final...
and DNA fingerprinting. Enzymes called DNAligases can rejoin cut or broken DNA strands. Ligases are particularly important in lagging strand DNA replication...
major NHEJ factor X4L4 (XRCC4-DNAligase4 complex). X4L4 stimulates WRN exonuclease activity that likely facilitates DNA end processing prior to final...
HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of...
endonucleases. At the replication fork, the gap in DNA after removal of the flap is sealed by DNAligase I, which repairs the nicks that are left between...
DNA polymerase (DNA-directed DNA polymerase, DdDP) Family A: DNA polymerase I; Pol γ, θ, ν Family B: DNA polymerase II; Pol α, δ, ε, ζ Family C: DNA polymerase...
of a DNA strand with no attached complement) known as a sticky end on each end of AATT. The overhang can then be used to ligate in (see DNAligase) a piece...
joining (MMEJ), and homologous recombination (HR): In NHEJ, DNALigase IV, a specialized DNAligase that forms a complex with the cofactor XRCC4, directly...
eukaryotes, newly synthesized lagging-strand DNA transiently contains nicks (before being sealed by DNAligase) and provides a signal that directs mismatch...