DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases.
^ abcGRCh38: Ensembl release 89: ENSG00000105486 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000056394 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
DNAligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role...
DNAligase 4 also DNAligase IV, is an enzyme that in humans is encoded by the LIG4 gene. DNAligase 4 is an ATP-dependent DNAligase that joins double-strand...
ligases include the word "ligase", such as in DNAligase, an enzyme commonly used in molecular biology laboratories to join together DNA fragments. However,...
DNAligase 3 also DNAligase III, is an enzyme that, in humans, is encoded by the LIG3 gene. LIG3 encodes ATP-dependent DNAligases that seal interruptions...
discontinuously and later linked together by the enzyme DNAligase to create the lagging strand during DNA replication. They were discovered in the 1960s by...
double-stranded DNA that originates in a linear form that is ligated by means of DNAligase to a covalently closed ring. In most cases, transcription of viral DNA can...
The ligase chain reaction (LCR) is a method of DNA amplification. The ligase chain reaction (LCR) is an amplification process that differs from PCR in...
The termini of the resulting linear monomers are ligated by the host DNAligase1 to generate the mature circular viroid RNA. Apscaviroid Apple dimple...
E3 ligases regulates diverse areas such as cell trafficking, DNA repair, and signaling and is of profound importance in cell biology. E3 ligases are...
Blunt ends are not always desired in biotechnology since when using a DNAligase to join two molecules into one, the yield is significantly lower with...
HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It is encoded by a gene of...
second component involves the bridging of DNA to DNAligase 4, by hXRCC4, with the aid of Cernunnos-XLF. DNA-PKcs and hXRCC4 are anchored to Ku70 / Ku80...
enzyme, DNAligase, fragments generated by restriction enzymes could be joined in new combinations, termed recombinant DNA. By recombining DNA segments...
and DNA fingerprinting. Enzymes called DNAligases can rejoin cut or broken DNA strands. Ligases are particularly important in lagging strand DNA replication...
RNase H to nick mRNA that is replaced with E. Coli DNA Polymerase I and sealed with E. Coli DNALigase. An optimization of this procedure relies on low...
DNA polymerase (DNA-directed DNA polymerase, DdDP) Family A: DNA polymerase I; Pol γ, θ, ν Family B: DNA polymerase II; Pol α, δ, ε, ζ Family C: DNA polymerase...
involved in DNA damage recognition of DNA double-strand breaks. Lysine 63-linked polyubiquitin chains are formed on H2AX histone by the E2/E3 ligase pair, Ubc13-Mms2/RNF168...
endonucleases. At the replication fork, the gap in DNA after removal of the flap is sealed by DNAligase I, which repairs the nicks that are left between...
adjacent DNA fragments can anneal. The DNA polymerase incorporates nucleotides to fill in any gaps. The DNAligase covalently joins the DNA of adjacent...
non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNAligase IV assembled with topo IIβ and PARP-1. This assemblage was all...
LIG4 syndrome (also known as Ligase IV syndrome) is an extremely rare condition caused by mutations in the DNALigase IV (LIG4) gene. Some mutations in...
artificial DNA primers can be used to start DNA synthesis at known sequences in a template DNA molecule. Polymerase chain reaction (PCR), ligase chain reaction...
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